Inhibition of cytochrome P450-dependent monooxygenases by an alkaloid fraction from Helietta apiculata markedly potentiate the hypnotic action of pentobarbital

Goloubkova, Tatiana; Heckler, E; Rates, Stela Maris Kuze; Henriques, João Antônio Pêgas; Henriques, Amélia Teresinha

doi:10.1016/s0378-8741(97)00139-6

Cited by 34 publications

(21 citation statements)

References 12 publications

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“…through interference with DNA or cytochrome P450 oxidases (Kanamori et al, 1986;Goloubkova et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Light-independent toxicity of furanocoumarins and furoquinolines can also occur; furoquinolines have been shown to cause frameshift mutations in Salmonella typhimurium due to lightindependent intercalation with DNA (Kanamori et al, 1986). Furanocoumarins can inhibit the activity of insect cytochrome P450 enzymes (Neal and Wu, 1994), while furoquinolines have been demonstrated to inhibit cytochrome P450 activity in rats (Goloubkova et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Effects of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans

2007

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The furoquinoline alkaloids skimmianine and dictamnine were tested for effects on the feeding and growth of larvae of the generalist lepidopteran, Spodoptera litura. Skimmianine was further investigated for toxic and phototoxic effects on the larvae of Trichoplusia ni, also a generalist species.In feeding experiments with S. litura, growth and consumption of larvae decreased with increasing concentration of furoquinolines; skimmianine caused a greater reduction in growth than dictamnine. In T. ni, dietary skimmianine reduced growth and consumption; when administered topically, it significantly reduced consumption but without a concomitant reduction in growth. Phototoxicity of skimmianine was not apparent in T. ni because UV light failed to increase the negative effects of the alkaloid on larvae.

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“…through interference with DNA or cytochrome P450 oxidases (Kanamori et al, 1986;Goloubkova et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans

2007

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“…These effects are classically related to central nervous system depressant drugs. However, this is not a specific test because compounds that interfere with biotransformation of pentobarbital by cytochrome P450 complex can also show the same effects [18]. The extract of C. decidua significantly inhibited the pentylenetetrazole-induced convulsions; increased latency of tonic convulsion and a decrease in the percentage of animals developing convulsions were seen in each group, which can be indicative of a more specific CNS effect due to action on the GABA system [19].…”

Section: Discussionmentioning

confidence: 99%

Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua

Goyal¹,

Nagori²,

Sasmal

2009

J Nat Med

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Capparis decidua (frock) Edgew (family Capparidaceae) is a xerophytic shrub, commonly known as karrel or ker, whose bark and shoot are used as analgesic, anti-inflammatory, hypolipidemic, and antidiabetic agents. The plant contains generous quantities of alkaloids. An alcoholic extract of aerial parts of C. decidua, including flowers and fruits, was screened for central nervous system (CNS) activity using conventional behavioral animal models. In the open field test all doses of C. decidua extract tested decreased the number of rearings, grooming, and fecal bolus (P < 0.001) when compared with control. In the barbiturate-induced sleeping test a significant (P < 0.001) a decrease in latency of sleeping and increase in sleeping time were observed at all doses (100, 200, and 300 mg/kg). C. decidua extract increased the percentage of animals exhibiting motor deficit in the rotarod test. In the pentylenetetrazole-induced seizures test the C. decidua extract dose-dependently decreased (P < 0.05) the number of animals with convulsions and increased convulsion latency (P < 0.001); none of the animals treated with extract died in the test. C. decidua extract decreased the duration of tonic hind leg extension in maximal electroshock-induced seizures (P < 0.001) when compared with control. The findings of the present animal study suggested that C. decidua has CNS depressant and anticonvulsant activities.

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“…In the potentiation of sodium pentobarbital sleep assay, the EH presented increase in sleeping time and this is classically related to the CNS depressant drugs (Willianson et al, 1996). Despite this test is not specific because compounds that interfere with biotransformation of pentobarbital by cytochrome P450 complex can show the same effects of CNS depressant drugs (Goloubkova et al, 1998). The mice treated with EH were partially protected from convulsions induced by PTZ, which can be indicative of a more specific effect due to action on GABA system (Löscher, 1998).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological activities investigation of crude extracts and fractions from Qualea grandiflora Mart.

Gaspi

Foglio

Carvalho

et al. 2006

Journal of Ethnopharmacology

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Inhibition of cytochrome P450-dependent monooxygenases by an alkaloid fraction from Helietta apiculata markedly potentiate the hypnotic action of pentobarbital

Cited by 34 publications

References 12 publications

Effects of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans

Effects of furoquinoline alkaloids on the growth and feeding of two polyphagous lepidopterans

Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua

Pharmacological activities investigation of crude extracts and fractions from Qualea grandiflora Mart.

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