Sedative and anticonvulsant effects of an alcoholic extract of Capparis decidua

Abstract

Capparis decidua (frock) Edgew (family Capparidaceae) is a xerophytic shrub, commonly known as karrel or ker, whose bark and shoot are used as analgesic, anti-inflammatory, hypolipidemic, and antidiabetic agents. The plant contains generous quantities of alkaloids. An alcoholic extract of aerial parts of C. decidua, including flowers and fruits, was screened for central nervous system (CNS) activity using conventional behavioral animal models. In the open field test all doses of C. decidua extract tested decreased the number of rearings, grooming, and fecal bolus (P < 0.001) when compared with control. In the barbiturate-induced sleeping test a significant (P < 0.001) a decrease in latency of sleeping and increase in sleeping time were observed at all doses (100, 200, and 300 mg/kg). C. decidua extract increased the percentage of animals exhibiting motor deficit in the rotarod test. In the pentylenetetrazole-induced seizures test the C. decidua extract dose-dependently decreased (P < 0.05) the number of animals with convulsions and increased convulsion latency (P < 0.001); none of the animals treated with extract died in the test. C. decidua extract decreased the duration of tonic hind leg extension in maximal electroshock-induced seizures (P < 0.001) when compared with control. The findings of the present animal study suggested that C. decidua has CNS depressant and anticonvulsant activities.

Green synthesis and biological activities of gold nanoparticles functionalized with Salix alba

“…Animals were acclimatized under red light (40 Watt red bulb) one hour before the start of experiment. After 30 minutes of treatment with diazepam (0.25 mg/kg), normal saline (10 ml/kg), CEW (50 and 100 mg/kg, i.p) and Au-WAs (5 and 10 mg/kg, i.p), each animal was placed in the center of the box and the numbers of lines crossed were counted (Archer, 1973;Goyal et al, 2009). …”

In vitro and in vivo antimicrobial activity of Algerian Hoggar Salvadora persica L. extracts against microbial strains from children's oral cavity

“…Clinical studies have shown that chewing sticks, when properly used, can be as efficient as toothbrushes in removing dental plaque due to the combined effect of mechanical cleaning and enhanced salivation (Goyal et al, 2009;Kayode and Omotoyinbo, 2009). A mouth rinse with aqueous Salvadora persica twigs extract caused a significant reduction (84%) in the adherence of bacterial cells (Streptococcus mutans) to buccal epithelial cells (Hammad and Sallah, 2005).…”

Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew

“…The plant has been reported for its Central Nervous System sedative and depressant [22,23], and antimicrobial properties [8,24,25]. Methanol and water extracts of C. decidua possessed hepatoprotective activity [26].…”