Influence of the introduction of a triphenylphosphine group on the anticancer activity of a copper complex

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

“…The change of intracellular Ca 2+ concentration is an indicator of cell apoptosis, and it can be detected by using the fluorescent probe Fluo-3Am. 65 As shown in Fig. 15A, the intracellular fluorescence intensity of the Eca-109 cells of the dosing groups was significantly enhanced, indicating a significant increase in intracellular Ca 2+ concentration.…”

“…rescent probe Fluo-3Am. 65 As shown in Fig. 15A, the intracellular fluorescence intensity of the Eca-109 cells of the dosing groups was significantly enhanced, indicating a significant increase in intracellular Ca 2+ concentration.…”

Investigation on chloro-bridged binuclear copper(ii) complexes as potent metallodrug candidates against colon cancer via chemical and biological assessments

“…Among the tested complexes 1-5, copper complex 1 was significantly taken up by the cells with 73 ng and 150 ng after 24 and 48 hours respectively than other complexes followed by complex 5 with 57 ng and 102 ng of internalization after the same time intervals. This study revealed that the proposed drug candidates 1-5 possess the ability to internalise into the cancer cells efficiently [46][47][48] (Fig. 13).…”

Piano-stool ruthenium(ii) complexes with maleimide and phosphine or phosphite ligands: synthesis and activity against normal and cancer cells

“…31 Li et al also reported the enhancement of anti-cancer activity with triphenylphosphine ligands in some copper complexes. 32 On the other side, Küster's group reported various η 6 -areneruthenium( ii ) phosphite complexes for the treatment of Alveolar Echinococcosis with cytotoxicity effect on human fibroblasts, Vero cells, and rat hepatoma cells. Authors used triethyl phosphite, triphenyl phosphite and triisopropyl phosphite as ligands and observed that the complexes with triethyl phosphite and triisopropyl phosphite are the most cytotoxic towards cancer cells.…”