Investigation on chloro-bridged binuclear copper(<scp>ii</scp>) complexes as potent metallodrug candidates against colon cancer <i>via</i> chemical and biological assessments

Sankar, Neethu; Devarajan, Badhmapriya; Manimuthu, Akilesh; Nattamai S. P., Bhuvanesh; Nallasamy, Dharmaraj; Velusamy, Kaveri Machampalayam

doi:10.1039/d3nj05335k

New J. Chem.

2024

DOI: 10.1039/d3nj05335k

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Investigation on chloro-bridged binuclear copper(ii) complexes as potent metallodrug candidates against colon cancer via chemical and biological assessments

Neethu Sankar,

Badhmapriya Devarajan,

Akilesh Manimuthu

et al.

Abstract: Synthesized binuclear copper(ii) complexes have been utilized for catechol oxidase mimicking activity, DNA/BSA interactions, molecular docking and pharmacological potential assessment against colon cancer and normal skin cells through in vitro method.

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3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N^∩O Chelating Hydrazones

Shalini,

Akilesh,

Sathiyaraj

et al. 2024

Applied Organom Chemis

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Using palladium hydrazone complex as a homogeneous catalyst for SMC, we synthesized a library of 15 variant 3‐arylcoumarins. In this context, we report a set of four coordinated palladium(II) hydrazone complexes 1 and 2 having the general formula [Pd(L)(Cl)(PPh3)] by reacting the precursor complex [PdCl2(PPh3)2] with the hydrazone ligands HL1 or HL2. Single crystal XRD and conventional spectroscopic techniques were employed to characterize both complexes. From the catalytic application point of view, the new complexes 1 and 2 were tested as homogeneous catalysts towards the conversion of 3‐chlorocoumarins into 3‐arylcoumarins by activating the challenging CCl functionality. A minimal catalyst loading of complex 2 (0.01 mol%), afforded a series of 3‐arylcoumarins with a maximum of 92% yield and reusability up to five cycles. The present methodology is simple and easy to carry out at room temperature utilizing a green solvent (ethanol) in an open flask with a spectrum of aryl boronic acids.

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3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N^∩O Chelating Hydrazones

Shalini,

Akilesh,

Sathiyaraj

et al. 2024

Applied Organom Chemis

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Investigation on chloro-bridged binuclear copper(ii) complexes as potent metallodrug candidates against colon cancer via chemical and biological assessments

Abstract: Synthesized binuclear copper(ii) complexes have been utilized for catechol oxidase mimicking activity, DNA/BSA interactions, molecular docking and pharmacological potential assessment against colon cancer and normal skin cells through in vitro method.

Cited by 1 publication

References 57 publications

3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N^∩O Chelating Hydrazones

3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N^∩O Chelating Hydrazones

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Investigation on chloro-bridged binuclear copper(ii) complexes as potent metallodrug candidates against colon cancer via chemical and biological assessments

Abstract: Synthesized binuclear copper(ii) complexes have been utilized for catechol oxidase mimicking activity, DNA/BSA interactions, molecular docking and pharmacological potential assessment against colon cancer and normal skin cells through in vitro method.

Cited by 1 publication

References 57 publications

3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N∩O Chelating Hydrazones

3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N∩O Chelating Hydrazones

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3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N^∩O Chelating Hydrazones

3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N^∩O Chelating Hydrazones