Piano-stool ruthenium(<scp>ii</scp>) complexes with maleimide and phosphine or phosphite ligands: synthesis and activity against normal and cancer cells

Juszczak, M.; Sahoo, Prithidipa; Kosińska, Aneta; Rybarczyk‐Pirek, Agnieszka J.; Wzgarda-Raj, Kinga; Tokarz, Paulina; Vasudevan, Saranya; Chworoś, Arkadiusz; Woźniak, Katarzyna; Rudolf, Bogna

doi:10.1039/d2dt04083b

Cited by 7 publications

(4 citation statements)

References 73 publications

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“…The plasmid relaxation assay was performed similarly to the procedure of Juszczak et al [ 122 ]. The pUC19 plasmid was isolated from the DH5α E. coli cells with Isolate II Plasmid Mini Kit (Meridian Bioscience, OH, USA) according to the manufacturer’s instruction.…”

Section: Methodsmentioning

confidence: 99%

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Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Mrozińska,

Kaczmarek,

Świerczyńska

et al. 2024

Materials

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The paper presents the study concerning the preparation and physio-chemical and biological properties of wool–copper (WO-Cu) materials obtained by the sputter deposition of copper onto the wool fibers. The WO-Cu material was subjected to physio-chemical and biological investigations. The physio-chemical investigations included the elemental analysis of materials (C, N, O, S, and Cu), their microscopic analysis, and surface properties analysis (specific surface area and total pore volume). The biological investigations consisted of the antimicrobial activity tests of the WO-Cu materials against colonies of Gram-positive (Staphylococcus aureus) bacteria, Gram-negative (Escherichia coli) bacteria, and fungal mold species (Chaetomium globosum). Biochemical–hematological tests included the evaluation of the activated partial thromboplastin time and pro-thrombin time. The tested wool–copper demonstrated the ability to interact with the DNA in a time-dependent manner. These interactions led to the DNA’s breaking and degradation. The antimicrobial and antifungal activities of the WO-Cu materials suggest a potential application as an antibacterial/antifungal material. Wool–copper materials may be also used as customized materials where the blood coagulation process could be well controlled through the appropriate copper content.

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Section: Methodsmentioning

confidence: 99%

“…Table 3. Average amino acid composition of wool [121,122]. [%] 0-0.5 /f 0.6-0.9 3.5-5 5.8-6.5 4-8 7-8 7-10 13-16 Amino acids (AA) abbreviations: a,b/ tri-or one-le er codes.…”

Section: Magnetron Spu(ering Modificationmentioning

confidence: 99%

Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Mrozińska,

Kaczmarek,

Świerczyńska

et al. 2024

Materials

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“…Moreover, triphenylphosphine can intercalate between DNA base pairs which increases anticancer activity. [30][31][32] The above-mentioned different mechanisms of action, ligand substitution kinetics, and various oxidation states contributed to potential redox activity, lower toxic effect, and higher cellular uptake efficiency give advantages to ruthenium and iridium complexes over platinum-based compounds. [33][34][35] Currently, two piano-stool ruthenium(II) complexes Ru(η 6 -pcymene)Cl 2 PPh 2 CH 2 OH (RuPOH) and Ru(η 6 -p-cymene)Cl 2 P(p-OCH 3 Ph) 2 CH 2 OH (RuMPOH) and two half-sandwich iridium(III) complexes Ir(η 5 -Cp*)Cl 2 PPh 2 CH 2 OH (IrPOH) and Ir(η 5 -Cp*)Cl 2 P(p-OCH 3 Ph) 2 CH 2 OH (IrMPOH) have been synthesized, physiochemically characterized and evaluated in vitro in terms of their potential anticancer activity in our research groups.…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, the presence of triphenylphosphine improves the antiproliferative potential of Ru complexes. Moreover, triphenylphosphine can intercalate between DNA base pairs which increases anticancer activity [30–32] . The above‐mentioned different mechanisms of action, ligand substitution kinetics, and various oxidation states contributed to potential redox activity, lower toxic effect, and higher cellular uptake efficiency give advantages to ruthenium and iridium complexes over platinum‐based compounds [33–35] …”

Section: Introductionmentioning

confidence: 99%

Cellular Mechanistic Considerations on Cytotoxic Mode of Action of Phosphino Ru(II) and Ir(III) Complexes

Wojtala,

Komarnicka,

Kyzioł

et al. 2023

Eur J Inorg Chem

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Two piano‐stool ruthenium(II) complexes Ru(η6‐p‐cymene)Cl2PPh2CH2OH (RuPOH) and Ru(η6‐p‐cymene)Cl2P(p‐OCH3Ph)2CH2OH (RuMPOH) and two half‐sandwich iridium(III) complexes Ir(η5‐Cp*)Cl2PPh2CH2OH (IrPOH) and Ir(η5‐Cp*)Cl2P(p‐OCH3Ph)2CH2OH (IrMPOH) have been studied in terms of potential anticancer activity on previously selected cell line (human lung adenocarcinoma). Based on experimental results obtained in monoculture in vitro model mechanistic considerations on the possible cellular modes of action have been carried out. ICP‐MS analysis revealed the higher cellular uptake for less hydrophobic Ir(III) complexes in comparison to the corresponding Ru(II) compounds. Cytometric analysis showed a predominance of apoptosis over the other types of cell death for all complexes. The apoptotic pathway was confirmed by a decrease in mitochondrial membrane potential and the activation of caspases‐3/9 for both Ru(II) and Ir(III) complexes. It was concluded that in the case of Ru(II) complexes the intense ROS generation is mainly responsible for the resulting cytotoxicity. The corresponding Ir(III) complexes trigger simultaneously at least three different cytotoxic pathways i.e., depletion of mitochondrial potential, activation of caspases‐dependent apoptosis, and ROS‐associated oxidation. Thus, it can be assumed that the final accumulation of toxic effects over time via parallel activation of different pathways results in the highest cytotoxicity in vitro exhibited by Ir(III) complexes when compared with Ru(II) complexes.

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Caged xanthone derivatives to promote mitochondria-mediated apoptosis in breast cancer cells

Wang,

Zheng,

Jiang

et al. 2024

Bioorganic & Medicinal Chemistry

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Piano-stool ruthenium(ii) complexes with maleimide and phosphine or phosphite ligands: synthesis and activity against normal and cancer cells

Abstract: In these studies, we designed and investigated cyto- and genotoxic potential of five ruthenium cyclopentadienyl complexes bearing different phosphine and phosphite ligands.

Cited by 7 publications

References 73 publications

Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

Cellular Mechanistic Considerations on Cytotoxic Mode of Action of Phosphino Ru(II) and Ir(III) Complexes

Caged xanthone derivatives to promote mitochondria-mediated apoptosis in breast cancer cells

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