Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages

Oh, Mi Mi; Kim, Jin Wook; Jin, Myeong Heon; Kim, Je Jong; Moon, Du Geon

doi:10.1038/aja.2011.153

Cited by 39 publications

(17 citation statements)

References 29 publications

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“…Previous animal studies simulating sleep deprivation have shown that sleep interruption significantly interrupts with the circadian rhythm of testosterone. 16 Groups of younger and older rats were kept in a sleep deprived state by placing them within a modified disk-over-water chamber, resulting in a significant decrease of testosterone in the older rats. Clinical studies on sleep disruption have also shown a significant relationship between the disruptions of nocturnal testosterone rhythm and sleep fragmentation.…”

Section: Discussionmentioning

confidence: 99%

Nocturnal polyuria and decreased serum testosterone: Is there an association in men with lower urinary tract symptoms?

Kim

Yoon

et al. 2013

Int J of Urology

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Objectives:To investigate the putative association between nocturia and decreased serum testosterone in men with lower urinary tract symptoms. Methods: Frequency volume charts and serum testosterone levels of patients visiting the outpatient clinic for lower urinary tract symptoms were collected and analyzed. Age, prostate volume, body mass index and the presence of comorbidities were accounted for. Frequency volume charts were analyzed for pathophysiological components of nocturnal polyuria, global polyuria, decreased nocturnal bladder capacity and increased frequency to identify associated risks. Frequency volume charts were also used to chart 8-h changes of volume, frequency and capacity to identify time diurnal interactions with risk factors based on serum testosterone levels. Results: A total of 2180 patients were enrolled in the study. Multivariate analysis showed testosterone decreased 0.142 ng/mL for every increase in nocturia, independent of other factors. Logistic regression analysis showed a significant difference between pathophysiological components. Decreased testosterone was shown to carry a significant independent risk for overall nocturia (odds ratio 1.60, 95% confidence interval 1.013-2.527, P = 0.044), and particularly nocturnal polyuria (odds ratio 1.934, 95% confidence interval 1.001-3.737, P = 0.027). Repeated measurement models showed patients with serum testosterone below 2.50 ng/mL to have a paradoxical increase in nocturnal urine volume at night. Conclusions: Nocturia, especially nocturnal polyuria, is associated with decreased serum testosterone. Patients with low serum testosterone show increased nocturnal urine output.

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Section: Discussionmentioning

confidence: 99%

Nocturnal polyuria and decreased serum testosterone: Is there an association in men with lower urinary tract symptoms?

Kim

Yoon

et al. 2013

Int J of Urology

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“…The MMPM, illustrated elsewhere [ 23 , 25 ], was selected to build the CSD model in this study. Rats from the CSD group were group housed (six rats in each arena) in modified multiple platform arenas during periods of sleep deprivation.…”

Section: Methodsmentioning

confidence: 99%

Effects of chronic sleep deprivation on bone mass and bone metabolism in rats

Wang

Chen

et al. 2016

J Orthop Surg Res

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BackgroundThis study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats.MethodsTwenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol (E2), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium.ResultsCompared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05).ConclusionsCSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers.

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“…The CSD rats were intervened by the modified multiple platform method (MMPM), which was proved available to build the CSD model [ 26 ]. The animals were group housed (six rats in each arena) in modified multiple platform arenas during CSD.…”

Section: Methodsmentioning

confidence: 99%

Effects of chronic sleep deprivation on glucose homeostasis in rats

Wang

Zhang

et al. 2016

Sleep Biol. Rhythms

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Epidemiological studies have shown that chronic sleep disturbances resulted in metabolic disorders. The purpose of this study was to assess the relationship between chronic sleep deprivation (CSD) and the glucose homeostasis in rats. Twenty-four rats were randomly divided into CSD group and control (CON) group. The CSD rats were intervened by a modified multiple platform method (MMPM) to establish an animal model of chronic sleep disturbances. After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) and an insulin tolerance test (ITT), and the body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, lipid profile group, and homeostasis model assessment-IR (HOMA-IR) were measured. Both the CSD and CON groups had an attenuation of weight gain after 3-month intervention. The plasma glucose level of CSD group was higher than that of the CON group during the IPGTT (P \ 0.01). The CSD rats showed a marked increase in HOMA-IR and ITT compared with the CON group (P \ 0.01). There were no significant differences of AST, ALT, creatinine, and most lipid parameters between the CSD and CON groups (P [ 0.05). The CSD has a marked effect on glucose homeostasis, comprising glucose intolerance and insulin resistance.

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Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages

Cited by 39 publications

References 29 publications

Nocturnal polyuria and decreased serum testosterone: Is there an association in men with lower urinary tract symptoms?

Nocturnal polyuria and decreased serum testosterone: Is there an association in men with lower urinary tract symptoms?

Effects of chronic sleep deprivation on bone mass and bone metabolism in rats

Effects of chronic sleep deprivation on glucose homeostasis in rats

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