Nocturnal polyuria and decreased serum testosterone: Is there an association in men with lower urinary tract symptoms?

Kim, Jin Wook; Oh, Mi Mi; Yoon, Cheol Yong; Bae, Jae Hyun; Kim, Je Jong; Moon, Du Geon

doi:10.1111/iju.12345

Cited by 18 publications

(29 citation statements)

References 25 publications

(59 reference statements)

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“…Since T therapy results in a sustained and marked decrease in body weight, WC, and BMI [151], weight loss associated with T treatment may contribute to the observed improvement in LUTS. Our findings are also supported by a number of human and animal studies demonstrating a strong independent association between the components of Met S and BPH/LUTS as discussed above [153]. …”

Section: Does Testosterone Therapy Improves Lower Urinary Tract Symptsupporting

confidence: 89%

“…Adjusted and unadjusted longitudinal models showed modest, positive effects of T therapy on LUTS, with 7.1% lower total IPSS over time (p=0.004) and 7.9% reduction of irritative scores (p<0.001) in T treated compared with untreated men, but no change in IPSS obstructive scores (p=0.33). Shigehara et al [143] found that at 6 months, T therapy with 250 mg of T enanthate every 4 weeks was associated with decreased nocturia, improved sleep conditions, and improved QoL, which in and of itself has been shown to improve endogenous T production [153]. T treatment has also been shown to improve voiding function, urinary symptoms and changes in bladder wall thickness observed with androgen deficiency [140141145].…”

Section: Does Testosterone Therapy Improves Lower Urinary Tract Symptmentioning

confidence: 99%

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Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

Traish

Johansen

2018

World J Mens Health

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Lower urinary tract function is modulated by neural, vascular and urethral and bladder structural elements. The pathophysiological mechanisms of lower urinary tract symptoms (LUTS) encompass prostate enlargement, alterations in urethra histological structure bladder fibrosis and alterations in pelvic neuronal and vascular networks, The complex pathophysiological relationship between testosterone (T) deficiency (TD) and the constellations LUTS, and metabolic dysfunction manifested in the metabolic syndrome (Met S) remains poorly understood. TD has emerged as one the potential targets by which Met S may contribute to the onset and development as well as worsening of LUTS. Because it has been recognized that treatment of men with Met S with T therapy ameliorates Met S components, it is postulated that T therapy may represent a therapeutic target in improving LUTS. Furthermore, the effect of TD on the prostate remains unclear, and often debatable. It is believed that T exclusively promotes prostate growth, however recent evidence has strongly contradicted this belief. The true relationship between benign prostatic hyperplasia, TD, and LUTS remains elusive and further research will be required to clarify the role of T in both benign prostatic hypertrophy (BPH) and LUTS as a whole. Although there is conflicting evidence about the benefits of T therapy in men with BPH and LUTS, the current body of literature supports the safety of using this therapy in men with enlarged prostate. As the population afflicted with obesity epidemic continues to age, the number of men suffering from Met S and LUTS together is expected to increase.

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Section: Does Testosterone Therapy Improves Lower Urinary Tract Symptsupporting

confidence: 89%

Section: Does Testosterone Therapy Improves Lower Urinary Tract Symptmentioning

confidence: 99%

Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

Traish

Johansen

2018

World J Mens Health

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“…Many reports have investigated the relationship between testosterone and LUTS, whereas few have focused on the relationship between testosterone and nocturia in men [21222324252627]. Recent studies have suggested that testosterone has an ameliorative effect on nocturia (Table 1).…”

Section: Relationship Between Testosterone and Nocturiamentioning

confidence: 99%

“…Another study involving 2,180 patients demonstrated that testosterone decreased 0.142 ng/mL for every time the patients woke at night to urinate, and that nocturia, especially nocturnal polyuria, was associated with decreased serum testosterone [22]. Kim et al [23] suggested that serum total testosterone levels may have a beneficial effect on lower urinary tract function, and showed that they were significantly lower in patients with 4 or more episodes of nocturia per night.…”

Section: Relationship Between Testosterone and Nocturiamentioning

confidence: 99%

“…Nocturnal polyuria is considered the most significant contributory factor to nocturia. Indeed, a cross-sectional study including 2,180 patients with nocturia found that nocturnal polyuria was significantly associated with lower testosterone levels, and that individuals with low testosterone levels had greater nocturnal urine volume [22]. …”

Section: Relationship Between Testosterone and Nocturiamentioning

confidence: 99%

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Testosterone Deficiency and Nocturia: A Review

Shigehara

Izumi

Mizokami

et al. 2017

World J Mens Health

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Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels. Therefore, patients with nocturia should receive appropriate treatment in order to improve their quality of life. Nocturia is generally treated by restricting nighttime water intake, as well as by the administration of medications, such as alpha-1 blockers, anticholinergic drugs, and desmopressin. Testosterone replacement therapy (TRT) is used worldwide as a treatment for many hypogonadal conditions. TRT represents an alternative treatment option for nocturia in hypogonadal men. However, limited information is currently available regarding the effects of TRT on nocturia in hypogonadal men, and further studies are required to reach more definitive conclusions.

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