Influence of nanosized delivery systems with benzyl nicotinate and penetration enhancers on skin oxygenation

Abramović, Zrinka; Šuštaršič, Urška; Teskač, Karmen; Šentjurc, Marjeta; Kristl, Julijana

doi:10.1016/j.ijpharm.2008.03.014

Cited by 31 publications

(20 citation statements)

References 37 publications

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“…Zeta potential of all vesicles was negative because P90G is a mixture of phosphatidylcholine, other phospholipids and fatty acids. In aqueous solution at pH~6, the negative phosphate residues of the phospholipids are distributed on the membrane surface leading to a negative potential value [31]. Being phosphatidylcholine a zwitterionic molecule, the orientation and conformation of its headgroup is not constant and can be influenced by binding or adsorption of the negatively charged molecule as well sodium hyaluronate, which can interact with choline groups on the bilayer surface forming a structured vesicle-polymer system [32].…”

Section: Discussionmentioning

confidence: 99%

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

et al. 2015

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“…[16][17][18][19][20][21][22][23][24][25] Numerous studies have demonstrated that microemulsions can improve drug transport through the skin compared with conventional topical preparations, such as gels, creams, and ointments. [26][27][28][29] Hence, microemulsions were used as the vehicle for transdermal delivery of citalopram in the present study.…”

Section: Introductionmentioning

confidence: 99%

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

Huang¹,

Tsai²,

Lin³

et al. 2013

IJN

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Abstract:The aim of this study was to evaluate the potential of microemulsions as a drug vehicle for transdermal delivery of citalopram. A computerized statistical technique of response surface methodology with mixture design was used to investigate and optimize the influence of the formulation compositions including a mixture of Brij 30/Brij 35 surfactants (at a ratio of 4:1, 20%-30%), isopropyl alcohol (20%-30%), and distilled water (40%-50%) on the properties of the drug-loaded microemulsions, including permeation rate (flux) and lag time. When microemulsions were used as a vehicle, the drug permeation rate increased significantly and the lag time shortened significantly when compared with the aqueous control of 40% isopropyl alcohol solution containing 3% citalopram, demonstrating that microemulsions are a promising vehicle for transdermal application. With regard to the pharmacokinetic parameters of citalopram, the flux required for the transdermal delivery system was about 1280 µg per hour. The microemulsions loaded with citalopram 3% and 10% showed respective flux rates of 179.6 µg/cm 2 and 513.8 µg/cm 2 per hour, indicating that the study formulation could provide effective therapeutic concentrations over a practical application area. The animal study showed that the optimized formulation (F15) containing 3% citalopram with an application area of 3.46 cm 2 is able to reach a minimum effective therapeutic concentration with no erythematous reaction.

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“…Compared to the conventional emulsions, microemulsions are characterized by low interfacial tension due to the high ratio of surfactant and co-surfactant responsible for good physical stability of formulation. On the other hand, high ratio of surfactant may affect the system's compatibility of formulation with the skin [144] . Recently, multiple W/O/W nanoemulsions as superior delivery system for acyclovir have been proposed [145].…”

Section: Micro-and Nano-emulsionsmentioning

confidence: 99%

(Phospho)lipid-based Nanosystems for Skin Administration

Vanić¹,

Holæter²,

Škalko‐Basnet

2015

CPD

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Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products

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Influence of nanosized delivery systems with benzyl nicotinate and penetration enhancers on skin oxygenation

Cited by 31 publications

References 37 publications

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology

(Phospho)lipid-based Nanosystems for Skin Administration

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