(Phospho)lipid-based Nanosystems for Skin Administration

Abstract

Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products

Current Trends in Development of Liposomes for Targeting Bacterial Biofilms

“…Such a structure facilitates encapsulation of a wide variety of drugs/active ingredients; hydrophilic into the inner water space, lipophilic inside bilayer and amphiphilic between these two regions. Liposomes are characterized by their phospholipid composition, morphology, particle size, surface properties and membrane rigidity/elasticity, parameters that determine their stability and interactions with biological milieu [ 38 , 39 , 40 ]. Many reviews report liposomes as the most widely used antimicrobial drug delivery nanosystem [ 7 , 34 , 35 , 36 , 37 , 41 , 42 , 43 ].…”

Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation

“…The potential of nanopharmaceuticals in treating local skin diseases, such as skin infections and wounds, has yet to be fully realized, however the extensive research efforts are expected to result in improved therapy outcome (DeLouise, 2012, Hurler and. Nanosized delivery systems offer an opportunity for extensive innovation in nanomedicine, making them an attractive target in drug product development (Vanić et al, 2015). Nanosized drug delivery systems designed for improved skin therapy are expected to exhibit all, or at least some of the desired features, namely to be able to protect drug from degradation as well as improve penetration of drug into/through the skin (Couvreur and Vauthier, 2006).…”

“…Already in 1988, the first topical liposomal preparation, Pevaryl Lipogel ® , produced by Cilag A.G. became available on the market. The fact that most topical liposomal preparations brought to the industrialization phase carry drugs that are targeted to the dermal region of the skin, shows that liposomal carriers are well-suited for this kind of application (Vanić et al, 2015).…”

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

“…216,217 Further, nanosizing of vesicles with incorporation of phytocompounds showed enhanced protective and beauty activity. [218][219][220][221] Recently, quercetin glycerosomes were developed in the size range of 80-110 nm with a unilamellar structure and showed enhanced skin protective activity. 222 This may be used in the future for the production of antioxidant skin cream.…”