Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

Manca, Maria Letizia; Castangia, Inés; Zaru, Marco; Nácher, Amparo; Valenti, Donatella; Fernàndez‐Busquets, Xavier; Fadda, Anna Maria; Manconi, Maria

doi:10.1016/j.biomaterials.2015.08.034

Cited by 171 publications

(125 citation statements)

References 34 publications

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“…In another study, nanoliposome-loaded CUR with 0.1% and 0.5% (w/v) sodium hyaluronate was prepared. 90 Both formulations were measured by cryogenic electron transmission microscopy and found that the shape was spherical with a single membrane. When CUR was encapsulated in the sodium hyaluronate liposomes, mean diameters and zeta potential were smaller than free CUR liposomes.…”

Section: Ligand-modified Cur Liposomesmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

284

187

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Section: Ligand-modified Cur Liposomesmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

284

187

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“…192 The combination of curcumin with hyaluronic acid enhances the bioavailability of curcumin in the skin and body, which leads to many novel nanoapproaches for the skin-based nanotherapautics and beauty. 193 Even though several phytocompound-encapsulated liposome technologies are used in cosmeceuticals and therapy, the nanosize of liposomes is still in the budding stages with the active phyto-derived compounds. Phytocompound-encapsulated liposomes will be an innovative technology in the near future for application in therapy-based beauty.…”

Section: Ganesan and Choimentioning

confidence: 99%

“…224 The same research group also developed curcumin-based nanohyalurosomes with a minimal particle size of 112 nm and showed enhanced skin beauty-based therapy. 193 From these studies, extracts can be used to develop nanovesicles, which could be efficiently used in the cosmeceutical sector, and it will give a broader scope of research and development for cosmeceutical products with multiple efficiencies.…”

Section: Nanoethosomes Glycerosomes and Hyalurosomesmentioning

confidence: 99%

“…Compounds vary from macro to nano and with skin penetration using different delivery techniques. 193,[247][248][249][250][251] Recently, resveratrol encapsulated in the solid lipid nanoparticle showed enhanced skin uptake with increased protection and antioxidant activity. 144 Solid lipid nanoparticles were compared nanostructured lipid carrier systems and found similar efficiencies with increased retention in the skin.…”

Section: Phytoconstituents In Nanosize Cosmeceuticals and Skin Therapymentioning

confidence: 99%

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Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

122

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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“…The incidence of skin inflammatory diseases (dermatitis, psoriasis, rash) has increased significantly in the last decades and bioflavonoids such as quercetin, curcumin and baicalin have been widely used for treatment of this injures [1,2,3,4]. Citrus fruits peels represent an important source of phenolic acids and flavonoids, mainly polymethoxyflavones (PMFs), flavanones and glycosylated flavanones [5,6].…”

Section: Introductionmentioning

confidence: 99%

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

Pleguezuelos-Villa

Mir-Palomo

Dı́ez-Sales

et al. 2018

Colloids and Surfaces B: Biointerfaces

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The article has 4636 words including ackwonledgment and references. The abstract has 127 words. There are 5 figures and 2 tables. Highlights Nanovesicles were small in size and monodispersed independently of the NA concentration. No citotoxity effects were observed in 3T3 fibroblasts treated with ultradeformable liposomes. Ultradeformable liposomes have the ability to reduce skin inflammation. Graphical abstract AbstractUltradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9 mg/mL). Nanovesicles were small size (~100 nm), regardless of the NA concentration used, and monodisperse (PI < 0.30). All formulations showed a high entrapment efficiency (~88%) and a highly negative zeta potential (around -30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts.In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (~ 10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher effectiveness of ultradeformable liposomes respect to betamethasone cream and NA dispersion in reducing skin inflammation in mice. Overall, it can conclude that NA ultradeformable liposomes can be considered as a promising formulation for the treatment of skin inflammatory diseases.

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Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

Cited by 171 publications

References 34 publications

Liposomal curcumin and its application in cancer

Liposomal curcumin and its application in cancer

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

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