“…Although the potential benefits of TiO 2 nanoparticles have been known since 1921 [ 64 ], the ability to destroy microorganisms has only been documented after 65 years [ 65 , 66 , 67 ]. Currently, it is known that the analgesic and antifungal activity of nano–TiO 2 is evident on 11 genera of filamentous fungi, 3 yeasts, 2 amoeba, 1 Apicomplexan, 1 diplomonad, 1 ciliate and 7 algae, including 1 diatom, fungal spores being generally more resistant than vegetative forms [ 45 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ].…”