Influence of Interleukin-28B Single-Nucleotide Polymorphisms on Progression to Liver Cirrhosis in Human Immunodeficiency Virus–Hepatitis C Virus–Coinfected Patients Receiving Antiretroviral Therapy

Abstract

The IL28B rs12979860 CC genotype is associated with a higher prevalence of cirrhosis in HIV-HCV-coinfected patients than CT/TT genotypes, suggesting that IL28B CC carriers may experience a more rapid progression of HCV-related liver fibrosis, perhaps as result of increased liver inflammation. Thus, access to HCV treatment is of utmost importance in IL28B CC carriers, in whom treatment response is better and in whom progression to cirrhosis might occur more rapidly.

Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese

“…Eurich et al (2012) reported that the "C" allele of IL-28B plays a protective role in the development of HCV-induced hepatocellular carcinoma. In contrast, Barreiro et al (2011) reported that the IL-28B rs12979860 "CC" genotype was associated with a higher prevalence of cirrhosis. However, the relationship between the IL-28B and IL-28Rα gene polymorphisms and LUTS has not been reported.…”

“…At present, the factors which caused the inflammation have been considered as the suspected cause for BPH (Sciarra et Association of the IL-28B receptor gene with LUTS al., 2007). IFN-λ3 has been shown to both cause and regulate inflammation in the liver upon infection by hepatitis C virus (Barreiro et al, 2011). Therefore, it has been considered that IL-28B gene polymorphism, which has been shown to be involved in inflammatory diseases (Bierne et al, 2012), might also play a role in the development of BPH with serious LUTS, and therefore IL-28B and IL-28R genetic variations have been considered to be potentially associated with LUTS.…”

Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

“…After our selection, 7 casecontrol studies including 1152 HCC and/or LC cases and 1326 controls fulfilled the inclusion criteria (Barreiro et al, 2011;Fabris et al, 2011;Falleti et al, 2011;Agundez et al, 2012;El-Awady et al, 2012;Eurich et al, 2012;Ren et al, 2012). The quality of the studies was considered acceptable for our meta-analysis.…”

“…There were 3 case-control studies (Barreiro et al, 2011;Fabris et al, 2011;, which had been performed to study the rs12979860 poly morphism and LC risk. The results of the meta-analysis are shown in Table 3.…”

“…During the last 3 years, a number of studies have as sessed the association between the IL-28B rs12979860 C/T polymorphism and risk of HCC and liver cirrhosis (LC) development in different populations; however, the results are inconsistent and inconclusive (Barreiro et al, 2011;Ren et al, 2012). Dif ferent methodologies have been used, but in particular, most studies have used a small sample size, and it is therefore not surprising that there has been a lack of rep lication in the various studies.…”