Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Suo, Guangjun; Zhao, Zhongyi

doi:10.4238/2013.september.19.1

Cited by 16 publications

(16 citation statements)

References 36 publications

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“…Our study demonstrates that microvascular invasion was a risk that increased HCC recurrence and affected the prognosis of HCC patients, which is consistent with previous findings [6,26,27]. A close relationship between cytokines and HCC has been reported in recent years [28][29][30][31]. IL6 is a crucial effector cytokine that is involved in hepatic physiology, including hepatoprotection, the acute-phase response, and mitogenesis in liver regeneration [11,32].…”

Section: Discussionsupporting

confidence: 93%

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

et al. 2016

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Section: Discussionsupporting

confidence: 93%

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

et al. 2016

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“…Additionally, one study found a significant association with cirrhosis, although most studies using cirrhosis or fibrosis as an outcome did not find an association. Four of the studies were meta‐analyses, with three of these focusing on rs12979860 and HCC and one focusing on fibrosis. Of these, two meta‐analyses found a positive association between rs12979860 and HCC and one found an association between fibrosis and rs12979860.…”

Section: Resultsmentioning

confidence: 99%

Host genetic factors associated with hepatocellular carcinoma in patients with hepatitis C virus infection: A systematic review

Walker

Peacock

Pedergnana

et al. 2018

Journal of Viral Hepatitis

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Summary Hepatitis C virus (HCV)‐infected patients are at risk of developing hepatocellular carcinoma (HCC). Individuals at heightened risk could be targeted by intensive follow‐up surveillance. We have conducted a systematic review of the literature to identify host genetic predisposition to HCC in HCV‐infected patients. A comprehensive search of Medline and Embase databases was performed, and the strength of evidence of associations for each gene on development of HCC was evaluated. We identified 166 relevant studies, relating to 137 different genes, or combinations thereof. Seventeen genes were classified as having “good” evidence of an association, a significant association was observed for 37 genes but this finding had not yet been replicated, 56 genes had mixed or limited evidence of an association, and 27 genes showed no association. IFNL3/4, TNF‐α and PNPLA3 genes had the most evidence of an association. There was, however, considerable heterogeneity in study design and data quality. In conclusion, we identified a number of genes with evidence of association with HCC, but also a need for more standardized approaches to address this clinically critical question. It is important to consider the underlying mechanism of these relationships and which are confounded by the presence of other HCC risk factors and response to therapy. We also identified many genes where the evidence of association is contradictory or requires replication, as well as a number where associations have been studied but no evidence found. These findings should help to direct future studies on host genetic predisposition to HCC in HCV‐infected patients.

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“…The variations in association of SNPs among studies conducted on Pakistani patients may have been due to different ethnic background of the patients. The polymorphism rs12979860 CT genotype has been associated with hepatocellular carcinoma and liver cirrhosis in seven different studies conducted previously on 1152 patients [Suo and Zhao, ]. In the cohort of 120 nonresponder patients, 59.1% (71/120) patients were in stage 2 of liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…The IL28B rs12980275 AA genotype on the other hand, was found to be associated with sustained virological response in Chinese patients with HCV genotype 1 or genotype 6 [Zhang et al, ]. It has also been disclosed that the genotypes of rs12979860 have been associated with development of hepatocellular carcinoma and liver cirrhosis after HCV infection [Suo and Zhao, ].…”

Section: Introductionmentioning

confidence: 99%

IL28Brs12980275 polymorphism shows association with response to treatment in Pakistani patients with Chronic Hepatitis C

Waryah

Devrajani

et al. 2015

J. Med. Virol.

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The aim of this study was to describe the genetic characteristics of Pakistani patients infected with hepatitis C virus (HCV) in relation to IL28B polymorphisms and its association to interferon and ribavirin treatment response. A total of 220 patients, infected with HCV were enrolled, out of which 100 were responders and 120 were nonresponders. The whole blood samples were collected to extract viral RNA and genomic DNA. PCR following the restriction fragment length polymorphism method was used to genotype IL28B rs12979860, rs8099917, and rs12980275 polymorphisms. Liver biopsies and HCV genotyping were performed in nonresponder patients. The rs12980275 AA genotype exhibited significant correlation to treatment response and was found in 62% of the responders and 37.5% of nonresponder patients, whereas AG genotype was noticed frequently in the nonresponder group (P < 0.0001). The rs12979860 CT and rs8099917 TT genotypes were found in 74% and 66% of the responders as compared to 58.3% and 50.8% in nonresponder patients (P = 0.001 and P = 0.032) respectively. HCV 3a genotypes were detected in 50.8% of the nonresponder patients. No significant association was detected between liver biopsy findings and IL28B SNPs (P > 0.05). The results showed the significant association of rs12980275 polymorphism with treatment response in HCV patients followed by rs12979860 and rs8099917. This is the first report describing the association of rs12980275 with response to HCV treatment from Pakistan. These findings may help in predicting the outcome of pegylated interferon and ribavirin treatment in HCV patients, and may reduce the side effects and cost of treatment in predicting non-responder patients.

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Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: a meta-analysis

Cited by 16 publications

References 36 publications

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

Host genetic factors associated with hepatocellular carcinoma in patients with hepatitis C virus infection: A systematic review

IL28Brs12980275 polymorphism shows association with response to treatment in Pakistani patients with Chronic Hepatitis C

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