Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

Chen, Fan; Liu, Shuanghai; Chen, Sheng; Wang, Zhaowen; Wu, Zehua; Ma, Kai; Fan, Junwei; Peng, Zhihai

doi:10.1007/s10147-016-1001-1

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…In addition, the TNM stage, microvascular invasion and the donor Rap1A rs494453 genotype AG/GG were independent risk factors for OS. These results were consistent with those of previous studies [7,22,23].…”

Section: Discussionsupporting

confidence: 94%

Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation

Zhang¹,

Wu²,

Yang³

et al. 2020

J. Cancer

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Background: Hepatocellular carcinoma (HCC) recurrence appears commonly after liver transplantation (LT), and it severely affected the long-term survival of patients. Previous studies have proved that Rap1A is involved in hepatocarcinogenesis and metastasis, and demonstrated the significant association between Rap1A gene rs494453 polymorphism and HCC. However, the relationship between Rap1A rs494453 polymorphism and HCC recurrence after LT remained unclear. Methods: A total of 74 HCC patients who underwent LT from July 2005 to June 2015 was analyzed. The genotypes of both donors and recipients had been confirmed as Rap1A rs494453. The independent risk factors that associated with HCC recurrence were investigated with univariate and multivariate logistic regression analysis. The recurrence-free (RFS) and overall survival (OS) were calculated with Cox regression analysis. The Rap1A rs494453 genotype frequencies were determined using the Χ² test and the minor allele frequencies (MAFs) of Rap1A rs494453 genotypes were calculated by Hardy-Weinberg equilibrium. Results: We found that the donor Rap1A rs494453 polymorphism was profoundly associated with HCC recurrence after LT. Moreover, the Milan criteria, microvascular invasion and donor Rap1A rs494453 genotype were proved to be independent risk factors for HCC recurrence. Patients with donor AG/GG genotypes had a distinct lower RFS and OS than AA genotype. The TNM stage, Milan criteria, microvascular invasion, and donor Rap1A rs494453 genotype were independent factors for the RFS of LT patients. Conclusions: Donor Rap1A rs494453 is a potential predictive marker for HCC recurrence risk after LT.

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Section: Discussionsupporting

confidence: 94%

Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation

Zhang¹,

Wu²,

Yang³

et al. 2020

J. Cancer

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“…Given its pivotal role in the proliferation, survival, and activation of CD8 + T cells and NK cells, IL-15 has been identified as an antitumor cytokine in several cancers, including neuroblastoma, HCC, and breast and colorectal cancer [ 27 – 31 ]. A close relationship between cytokine gene polymorphisms and HCC and HCC prognosis has been reported in recent years [ 10 , 20 , 21 ]. The potential association between the IL-15 gene polymorphisms and HCC recurrence and prognosis has been described in several studies.…”

Section: Discussionmentioning

confidence: 93%

“…Although several criteria are available for transplant patient selection, they have limitations for determining clinical outcome. Molecular markers and genetic variants could provide supplemental and useful information for predicting the clinical outcome and improve the selection of patients for adjuvant therapies after LT in addition to the clinical factors [ 9 , 10 ]. As such, it is a challenge to identify patients who are with a greater risk for HCC recurrence after LT and potential biomarkers for prognosis prediction.…”

Section: Introductionmentioning

confidence: 99%

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Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation

Zhang

Liu

Xu³

et al. 2017

Disease Markers

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Objective To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT. Methods A total of 112 liver transplant patients with HBV-related HCC were enrolled. IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients. Results Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT. In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT. Kaplan-Meier survival analysis demonstrated that patients with recipient IL-15 rs10519613 CA/AA genotypes had a decreased disease-free survival and overall survival than those with the CC genotype. Recipient IL-15 rs10519613 genetic variant could improve survival prediction when combined with the UCSF criteria. Furthermore, Cox proportional hazard regression analysis revealed that tumor size (p = 0.012, p = 0.623), tumor thrombus (p = 0.011, p = 0.015), UCSF criteria (p = 0.471, p = 0.013), and recipient IL-15 rs10519613 genotype (p = 0.039, p = 0.008) were independent factors of predicting DFS and OS. Conclusions Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.

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Interleukin-6-572 promoter gene polymorphism and its association with chronic hepatitis C-induced hepatocellular carcinoma: an Egyptian study

et al. 2017

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Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

Abstract: Our data suggest that donor IL6 rs2069852 polymorphisms may be a potential genetic marker for HCC recurrence after liver transplantation in the Han Chinese population.

Cited by 7 publications

References 44 publications

Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation

Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation

Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation

Interleukin-6-572 promoter gene polymorphism and its association with chronic hepatitis C-induced hepatocellular carcinoma: an Egyptian study

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