Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation

Abstract

Objective To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT. Methods A total of 112 liver transplant patients with HBV-related HCC were enrolled. IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients. Results Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT. In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT. Kaplan-Meier survival analysis demonstrated that patients with recipient IL-15 rs10519613 CA/AA genotypes had a decreased disease-free survival and overall survival than those with the CC genotype. Recipient IL-15 rs10519613 genetic variant could improve survival prediction when combined with the UCSF criteria. Furthermore, Cox proportional hazard regression analysis revealed that tumor size (p = 0.012, p = 0.623), tumor thrombus (p = 0.011, p = 0.015), UCSF criteria (p = 0.471, p = 0.013), and recipient IL-15 rs10519613 genotype (p = 0.039, p = 0.008) were independent factors of predicting DFS and OS. Conclusions Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.

Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation

“…In previous studies, Rap1A gene over-expression had been reported in various cancers, including ovarian cancer [10], breast cancer [18], and OCSCC [13]. The relationship between SNP genotype and HCC recurrence after LT has been reported in VEGF gene [19], IL-15 gene [20] and HPSE gene [21], signifying that the SNP genotype of hosts, including recipients and donors, has a significant role in the progression of HCC recurrence after LT.…”

Association of Polymorphisms in Inflammation Genes With the Prognosis of Advanced Non-Small Cell Lung Cancer Patients Receiving Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

“…Two studies showed that rs10519613 in IL15 was associated with the risk of minimal residual disease (MRD) in pediatric acute lymphoblastic leukemia (57,58). Zhang et al (59) observed that rs10519613 was associated with poor prognosis of HBV-related hepatocellular carcinoma after liver transplantation. In this study, we found that rs10519613 was associated with worse PFS and OS in advanced NSCLC patients treated with EGFR-TKI.…”

Seven gene signature explores the impact of DAAs on the appearance of hepatocellular carcinoma in HCV infected patients

“…There is much focus on genetic determinants and the development of HCC after DAAs therapy in recent years such as human leukocyte antigen, IL28B, IL-15 and OAS variants [ 10 , 12 , 28 , 29 , 30 , 31 ].…”