Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese

Le, Xiao Feng; Gao, Linbo; Wang, Qiang

doi:10.4238/2015.september.9.8

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…However, chronic periodontitis is still poor understood and the relationship between rs12979860 and rs8099917 and CP has not been reported till now but our results showed that these SNPs were associated with susceptibility to CP. Our finding revealed that most frequently genotypes in CP patients were CT + TT for rs12979860 and GT + GG for rs8099917 which differs from the study of Barreiro et al [43] and Rizk et al [49] but in agreement with many studies by Xiao et al [21], Derbala et al [45], Egli et al [47], Eurich et al [48]. …”

Section: Discussionsupporting

confidence: 81%

“…Recently, Xiao et al [21], Rauch et al [44], Derbala et al [45], Lampertico et al [46], Egli et al [47], Eurich et al [48] have reported that IL-28B polymorphisms associate with the susceptibility to the hepatitis B or C viruses infections, influenza and lower urinary tract symptoms (LUTS). Xiao et al [21] determined the relationship between IL-28B rs12979860 and rs8099917 SNPs and LUTS in Chinese patients.…”

Section: Discussionmentioning

confidence: 99%

“…Xiao et al [21] determined the relationship between IL-28B rs12979860 and rs8099917 SNPs and LUTS in Chinese patients. In the IL-28B rs12979860 and IL-28Rα rs10903035 also IL-28B rs8099917 and IL-28Rα rs10903035 interactions analysis, they found that the CC + AG/GG, CT + AG/GG; and TT + AG/GG, GT + AG/GG genotypes were significantly less frequent in the patients compared to the controls.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several studies have revealed that genetic variations such as single nucleotide polymorphisms (SNPs) at or near the IL-28B gene can affect the natural history of chronic infections [19–21]. …”

Section: Introductionmentioning

confidence: 99%

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The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population

et al. 2017

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BackgroundChronic Periodontitis (CP) is a common inflammatory disease affects supporting tissues of the teeth and can lead to tooth loss. The objective of this study was to determine the relationship between polymorphisms in the IL-28B gene and chronic periodontitis in an Iranian population.MethodsTwo hundred and ten CP patients and one hundred healthy subjects were enrolled in the present case-control study. The rs12979860 and rs8099917 SNPs were identified using RFLP and T-ARMS-PCR methods respectively.ResultsSNP analysis revealed that the G allele of rs8099917 SNP and T allele of rs12979860 SNP increased susceptibility to CP compared to the A allele and C allele (p < 0.0001, OR = 2.712, CI = 1.783-4.126; p < 0.0001, OR = 2.538, CI = 1.784-3.613 respectively). In addition, the CT/GT, TT/GG and TT/GT haplotypes were predominant in CP patients and significantly associated with the increased risk of CP.Conclusion IL-28B polymorphisms may be useful predictive factors for chronic periodontitis and correlated to the susceptibility to CP infection in our population.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population

et al. 2017

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“…So far, only one study has linked SNPs in genes involved in the IFN-λ signaling pathway with an increased risk of bacterial infections. Xiao et al showed that SNP rs10903035 with G allele in the IL28RA was associated with significantly less frequent urinary tract infection (178).…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Interferon Lambda: Modulating Immunity in Infectious Diseases

2017

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Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade. Thereby hundreds of IFN-stimulated genes are induced, which modulate various immune functions via complex forward and feedback loops. When compared to the well-characterized IFN-α signaling cascade, three important differences have been discovered. First, the IFNLR is not ubiquitously expressed: in particular, immune cells show significant variation in the expression levels of and susceptibilities to IFN-λs. Second, the binding affinities of individual IFN-λs to the IFNLR varies greatly and are generally lower compared to the binding affinities of IFN-α to its receptor. Finally, genetic variation in the form of a series of single-nucleotide polymorphisms (SNPs) linked to genes involved in the IFN-λ signaling cascade has been described and associated with the clinical course and treatment outcomes of hepatitis B and C virus infection. The clinical impact of IFN-λ signaling and the SNP variations may, however, reach far beyond viral hepatitis. Recent publications show important roles for IFN-λs in a broad range of viral infections such as human T-cell leukemia type-1 virus, rotaviruses, and influenza virus. IFN-λ also potentially modulates the course of bacterial colonization and infections as shown for Staphylococcus aureus and Mycobacterium tuberculosis. Although the immunological processes involved in controlling viral and bacterial infections are distinct, IFN-λs may interfere at various levels: as an innate immune cytokine with direct antiviral effects; or as a modulator of IFN-α-induced signaling via the suppressor of cytokine signaling 1 and the ubiquitin-specific peptidase 18 inhibitory feedback loops. In addition, the modulation of adaptive immune functions via macrophage and dendritic cell polarization, and subsequent priming, activation, and proliferation of pathogen-specific T- and B-cells may also be important elements associated with infectious disease outcomes. This review summarizes the emerging details of the IFN-λ immunobiology in the context of the host immune response and viral and bacterial infections.

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Investigate the relationship between Bacillus coagulans and its inhibition of chemotherapy‐induced lung cancer resistance

Ting,

Wang,

Liao

et al. 2024

Biotech and App Biochem

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Lung cancer is a leading cause of death globally, with lung adenocarcinoma being the most common subtype. Despite advancements in targeted therapy, drug resistance remains a major challenge. This study investigated the impact of Bacillus coagulans on drug resistance in lung adenocarcinoma cells. The cells were pretreated with B. coagulans culture filtrate (BCCF), and functional assays were performed, including cell proliferation, cell cycle, apoptosis, and immunofluorescence staining. Results showed that BCCF induced cell cycle arrest at the S phase, reducing cell proliferation and suppressing drug resistance marker P‐glycoprotein expression in BCCF‐treated resistant cells rather than BCCF‐treated control cells. Moreover, drug‐resistant cells exhibited the ability for epithelial‐mesenchymal transition, which could contribute to their necrosis through the iron‐mediated cell death pathway upon BCCF treatment. Proteomic analysis identified downregulation of DNA mismatch repair protein PMS2 after BCCF treatment. These findings suggest that B. coagulans may modulate the DNA repair pathway, influencing drug resistance in lung adenocarcinoma cells. In conclusion, this study highlights the potential impact of B. coagulans on drug‐resistant lung adenocarcinoma cells. Further investigation and understanding of the regulatory mechanisms by which B. coagulans modulates drug resistance in lung adenocarcinoma can aid in the development of more effective treatment strategies to improve the prognosis of lung cancer patients.

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Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese

Cited by 6 publications

References 31 publications

The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population

The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population

Interferon Lambda: Modulating Immunity in Infectious Diseases

Investigate the relationship between Bacillus coagulans and its inhibition of chemotherapy‐induced lung cancer resistance

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