The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population

Abstract

BackgroundChronic Periodontitis (CP) is a common inflammatory disease affects supporting tissues of the teeth and can lead to tooth loss. The objective of this study was to determine the relationship between polymorphisms in the IL-28B gene and chronic periodontitis in an Iranian population.MethodsTwo hundred and ten CP patients and one hundred healthy subjects were enrolled in the present case-control study. The rs12979860 and rs8099917 SNPs were identified using RFLP and T-ARMS-PCR methods respectively.ResultsSNP analysis revealed that the G allele of rs8099917 SNP and T allele of rs12979860 SNP increased susceptibility to CP compared to the A allele and C allele (p < 0.0001, OR = 2.712, CI = 1.783-4.126; p < 0.0001, OR = 2.538, CI = 1.784-3.613 respectively). In addition, the CT/GT, TT/GG and TT/GT haplotypes were predominant in CP patients and significantly associated with the increased risk of CP.Conclusion IL-28B polymorphisms may be useful predictive factors for chronic periodontitis and correlated to the susceptibility to CP infection in our population.

Conformity of the Real-Ear Aided Response With the Target Response From the Desired Sensation Level V5 Formula

“…This finding indicates that the mentioned factors do not affect the difference between target and measured curves. Heidari and Sagheb (2006) showed that Fars and Baluch children are different regarding head and face type indicators, phenotypes [17], and the effectiveness of the factors mentioned above in the results of real-ear measurements [14]. Nevertheless, the results of the current study indicated no significant difference between Fars and Baluch children in terms of predicted and measured curves.…”

“…In terms of anatomical features of the ear, the outer ear of girls and women is smaller than boys and men [15,16]. Regarding head and face, there is a difference between the two Iranian populations of Fars and Baluch [17,18]. In addition, the asymmetry between the dimensions of the two ears has been reported in some studies [19,20].…”

Interferon Lambda: An Anonymous Warrior of Host-Microbial Fray in The Pathogenesis of Periodontal Diseases

“…A genomic investigation by Zahra et al, found a connection between periodontal infection and two single nucleotide polymorphisms of IFN-λ2, rs8099917 and rs12979860. 56 As reported by Shivaprasad et al, patients with periodontitis have more IFN-λs levels than periodontally healthy people do. 57 Additional researches by Shivaprasad et al, show that IFN-λ1 is highly expressed in the aggressive form of periodontitis, whereas IFN-λ2 in chronic form.…”

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“…The reason for this discrepancy can be due to the ethnic differences between the studied populations and other differences in sample size and age groups. Smoking has been identified as a major environmental risk factor associated with increased incidence and severity of periodontitis 15 . Thus, smokers were excluded from our study to have less confounding factors when analyzing any genetic association with periodontitis.…”