Influence of Hepatitis B immunization to prevent vertical transmission of Hep-B virus in infants bam from Hep-B positive mother

Fitria, Liza; Gunardi, Hartono; Akib, Arwin Ap

doi:10.14238/pi50.6.2010.321-5

Cited by 4 publications

(6 citation statements)

References 2 publications

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“…Doctors who believe in high efficacy of Hib vaccine was 4.74 times more frequent to give immunization. [7][8][9][10] This data showed that physicians' attitude and knowledge contributes to immunization coverage.…”

Section: -mentioning

confidence: 87%

“…[3][4][5][6] Effectiveness study of hepatitis B immunization without HBIg to prevent vertical transmission in infants born to HBsAg positive mother in Jakarta was between 70-90%. [5][6][7][8] This data showed the importance of private practice to increase birth dose HB immunization coverage as Indonesia is classified as intermediate to high endemicity for hepatitis B infection. [6][7][8][9] Birth dose OPV was given immediately after birth by 24% of GPs and 8% of pediatricians.…”

Section: -mentioning

confidence: 99%

“…[5][6][7][8] This data showed the importance of private practice to increase birth dose HB immunization coverage as Indonesia is classified as intermediate to high endemicity for hepatitis B infection. [6][7][8][9] Birth dose OPV was given immediately after birth by 24% of GPs and 8% of pediatricians. This immediate immunization was appropriate for babies delivered at home.…”

Section: -mentioning

confidence: 99%

“…From that survey, it was reflected that pediatricians have big role in increasing pneumococcal immunization coverage. [8][9][10][11] Majority of GPs (62%) and pediatricians (74%) agreed that rotavirus vaccine needed to be given but majority of GPs (52%) had never used it and pediatricians had used it with variable frequency. A survey in India showed that majority of pediatricians used rotavirus vaccine in 80.2% of their patients.…”

Section: -mentioning

confidence: 99%

“…This result was similar to a survey in US which stated that 84.9% of family doctors gave MMR immunization routinely in practice. [5][6][7][8] Majority of GPs and pediatricians never used HPV vaccine. Factors influencing HPV vaccine usage were parental attitude, gender of the doctor, knowledge about HPV, and the trust to medical institution.…”

Section: -mentioning

confidence: 99%

See 4 more Smart Citations

Profile of Immunization Practice by General Practitioners and Pediatricians in Private Setting

Soedjatmiko¹,

Gunardi²,

Satari³

et al. 2017

mkb

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Basic immunization coverage in Indonesia in 2013 was still low (59.2%) (IBHS, 2013). Physicians' attitude and practice were among the determinant factors of a successful immunization program. This survey aimed to describe general practitioner's (GP) and pediatrician's attitude towards immunization and its coverage in private practices. This cross-sectional study was performed by distributing questionnaires consisting of 5 items on opinion and 10 items on immunization practices to 100 respondents in November 2014. Completed questionnaires were obtained from 29 GPs and 65 pediatricians. Most respondents considered that the Expanded Program in Immunization vaccine should be given. First dose of hepatitis B vaccine was mostly given in the first 12 hours after birth (90% GPs and 74% pediatricians). Oral polio vaccine was mostly given shortly before hospital discharge (65% of GPs and 81% pediatricians) while the DTwP-HB-Hib vaccine were given by 27% of GPs and 21% of pediatricians to >75% patients. Pneumococcal, rotavirus, hepatitis A, typhoid, and influenza vaccines were provided by less than 25% GPs and pediatricians, except for the influenza vaccine which was provided by 31% pediatricians. MMR vaccine was given to >75% patients by 16% of GPs and 29% of pediatricians. This pilot survey of immunization practice in private setting might be the first study in Indonesia that this can be considered as a preliminary report of immunization in private setting. Further studies need to be done, especially regarding problems in immunization in private practices. [MKB. 2017;49(4)

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confidence: 87%

Section: -mentioning

confidence: 99%

Section: -mentioning

confidence: 99%

Section: -mentioning

confidence: 99%

Section: -mentioning

confidence: 99%

See 3 more Smart Citations

Profile of Immunization Practice by General Practitioners and Pediatricians in Private Setting

Soedjatmiko¹,

Gunardi²,

Satari³

et al. 2017

mkb

Self Cite

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Establishment of anti-HBcAg Monoclonal Antibodies for Sandwich ELISA Application by Iliac Method Utilizing Incomplete Adjuvant

Septisetyani¹,

Herlina²,

Kusumawati³

et al. 2021

International Journal on Advanced Science, Engineering and Information Technology

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The prevalence of hepatitis B virus (HBV) infection in Indonesia was moderate in 2013. This makes an appropriate action has to be taken immediately. In an attempt to evaluate our candidate HBV vaccine efficacy, we generated monoclonal antibodies specific to HBcAg for sandwich ELISA application for research purposes. Monoclonal antibodies are generally developed using hybridoma technology by isolating B cells from spleen or lymph nodes followed by fusion with myeloma cells. This study generated hybridoma by modifying the iliac lymph node method and used incomplete Freund's adjuvant to emulsify the antigen. For this purpose, an elevenweek-old BALB/c mouse was immunized with a single shot recombinant HBcAg water in oil emulsion intramuscularly at the mouse tail base. After one month, besides enlargement of the medial iliac lymph nodes, we also found that the sub-iliac lymph nodes were enlarged. In two different fusion attempts, the single B cells were then isolated from each lymph node and fused with SP2/0-Ag14 mouse myeloma cells. Hybridoma cells derived from both lymph nodes were screened by ELISA coated with HBcAg peptide. As a result, we obtained two positive wells of hybridoma polyclones from each medial iliac and sub-iliac-derived B lymphocyte. After monoclonalization, we obtained candidate anti-HBcAg monoclonal antibodies as either capture or detection antibodies. Furthermore, we successfully retrieved hybridoma clones 9.3, 9.4, and 9.5, which could produce monoclonal antibodies for sandwich ELISA application.

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Hepatitis B virus infection in Indonesia

Yano

Utsumi

Lusida

et al. 2015

WJG

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Approximately 240 million people are chronically infected with hepatitis B virus (HBV), 75% of whom reside in Asia. Approximately 600000 of infected patients die each year due to HBV-related diseases or hepatocellular carcinoma (HCC). The endemicity of hepatitis surface antigen in Indonesia is intermediate to high with a geographical difference. The risk of HBV infection is high in hemodialysis (HD) patients, men having sex with men, and health care workers. Occult HBV infection has been detected in various groups such as blood donors, HD patients, and HIV-infected individuals and children. The most common HBV subgenotype in Indonesia is B3 followed by C1. Various novel subgenotypes of HBV have been identified throughout Indonesia, with the novel HBV subgenotypes C6-C16 and D6 being successfully isolated. Although a number of HBV subgenotypes have been discovered in Indonesia, genotype-related pathogenicity has not yet been elucidated in detail. Therefore, genotype-related differences in the prognosis of liver disease and their effects on treatments need to be determined. A previous study conducted in Indonesia revealed that hepatic steatosis was associated with disease progression. Pre-S2 mutations and mutations at C1638T and T1753V in HBV/B3 have been associated with advanced liver diseases including HCC. However, drug resistance to lamivudine, which is prominent in Indonesia, remains obscure. Although the number of studies on HBV in Indonesia has been increasing, adequate databases on HBV infection are limited. We herein provided an overview of the epidemiology and clinical characteristics of HBV infection in Indonesia.

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Influence of Hepatitis B immunization to prevent vertical transmission of Hep-B virus in infants bam from Hep-B positive mother

Cited by 4 publications

References 2 publications

Profile of Immunization Practice by General Practitioners and Pediatricians in Private Setting

Profile of Immunization Practice by General Practitioners and Pediatricians in Private Setting

Establishment of anti-HBcAg Monoclonal Antibodies for Sandwich ELISA Application by Iliac Method Utilizing Incomplete Adjuvant

Hepatitis B virus infection in Indonesia

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