Influence of changes in the composition of an acrylic bone cement on its polymerization kinetics

Abstract

It has been suggested in the literature that a lower polymerization rate of an acrylic bone cement is favorable for the in vivo longevity of a cemented arthroplasty. The present work was a study of the influence of three changes in the composition of an acrylic bone cement (when taken separately) on the cement polymerization rate at 37 degrees C (assumed to be the temperature in the bone bed during a cemented arthroplasty) [k']. The changes were the amount of copolymer as a proportion of the total powder weight (in cements in which there is a copolymer in the powder), the amount of DMPT as a proportion of the total volume of the liquid monomer, and the accelerator. k' was calculated using values of the activation energy and the frequency factor (assuming the polymerization reaction is Arrhenius in nature) that were computed from measurements made using the nonisothermal mode of differential scanning calorimetry. Statistical analysis (one-way ANOVA, with Bonferroni correction, and factorial ANOVA) of the k' values showed that the change in accelerator had a significant influence on k'. The importance of this finding, together with results from two relevant literature reports, is discussed within the context of the use of modified bone cements in cemented arthroplasties.

Not all approved antibiotic-loaded PMMA bone cement brands are the same: ranking using the utility materials selection concept

“…This was obtained using differential scanning calorimetry (DuPont 910; DuPont Instruments, Wilmington, DE, USA) and protocols given in our previous work [13]. The cement dough (3-5 mg) was heated from its initial temperature to a final temperature of 150°C, at 15 K min -1 .…”

“…In treating the results, it was assumed that an Arrhenius relationship exists between the rate constant for the polymerization of the cement (k) [in s -1 ] and its temperature during the polymerization, T; that is, [13] …”

Injectable Bone Cements for Spinal Column Augmentation: Materials for Kyphoplasty/Vertebroplasty

“…[40][41][42] This variability in duration of the various phases of the polymerizing cement poses a problem for physicians since it directly affects the time window available for safe injection. 43 It has been noted by many authors that a change of only a few degrees in ambient or cement component temperature may lead to substantial deviations in the duration of the injection phase.…”

Influence of strontia on various properties of Surgical Simplex® P acrylic bone cement and experimental variants

“…All details regarding the use of the data in the thermogram (heat flow per mass of cement used vs. cement temperature) to obtain k, lnA and E a have been given previously [40]. At each heating rate, E a and ln A were obtained, from which the overall means of these parameters were calculated.…”