Influence of strontia on various properties of Surgical Simplex® P acrylic bone cement and experimental variants

Lewis, Gladius; Xu, Jie; Madigan, S.; Towler, Mark R.

doi:10.1016/j.actbio.2007.03.010

Cited by 19 publications

(18 citation statements)

References 40 publications

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“…It is known that calcium phosphate with a Ca : P ratio of 1.0 to 2.0 is biocompatible and HA (Ca 10 (PO 4 ) 6 (OH) 2 ) is a ceramic with Ca : P ratio of 1.67 having a composition similar to natural bone. Its surface is highly reactive and lead to favorable attachment of bone cells having osseoconductive and osseoinductive effects.…”

Section: Introductionmentioning

confidence: 99%

“…All commercially available acrylic cements are prepared by mixing liquid and solid powder components. The compositions of powder and liquid parts may have some variations but in general the powder part contains poly(methyl methacrylate) polymer (PMMA) or PMMA-based copolymers, benzoyl peroxide (BPO) initiator, radiopacifier, 1,2 and sometimes antibiotics. 3,4 The liquid part includes methyl methacrylate (MMA) monomer, N,N-dimethyl-p-toluidine (DMPT) accelerator, hydroquinone (HQ) inhibitor to prevent premature polymerization and sometimes a crosslinking agent such as ethylene glycol dimethacrylate (EGDMA).…”

Section: Introductionmentioning

confidence: 99%

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Effects of ingredients on thermal and mechanical properties of acrylic bone cements

Endoğan

Şerbetçi

Hasırcı

2009

J of Applied Polymer Sci

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There is a very delicate relation between the amounts of all the ingredients present in the cement composition and the properties of the product. In this study, homogeneous poly(methyl methacrylate) (PMMA) microspheres were prepared by suspension polymerization technique, and used in cement formulations. Various acrylic cements with different compositions were prepared by using PMMA microspheres, methyl methacrylate (MMA) monomer, radiopaque agent of barium sulfate (BaSO 4 ), inorganic particles of hydroxyapatite (HA), initiator and chain stopping agent of 1-dodecyl mercaptan (DDM). The effects of these additives on mechanical and thermal properties of the resultant cements were examined. Addition of 8% HA relative to the solid parts caused an increase in both tensile and compressive strengths from 20.40 to 25.20 MPa, and from 84.04 to 89.57 MPa, respectively, while curing temperature was decreased about 3 degrees. Chain stopping agent of DDM caused a sharp decrease about 30 degrees in the curing temperature. Radiopaque agent of barium sulfate caused inverse effect on mechanical and thermal properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of ingredients on thermal and mechanical properties of acrylic bone cements

Endoğan

Şerbetçi

Hasırcı

2009

J of Applied Polymer Sci

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“…9 mm, respectively. The protocols used for finishing the specimens, accepting specimens for testing, conditioning the accepted specimens, performing the tests, and treating the results to obtain the fracture toughness (K IC ) of the cement were the same as those given in our previous work [30].…”

mentioning

confidence: 99%

“…Measurement continued until there was no observable increase in mass gain. Details of all the steps involved in using the mass gain versus time in PBS results to compute the PBS diffusion coefficient (D PBS ) were given in our previous work [30].…”

mentioning

confidence: 99%

“…The protocols used and the steps employed in treating the results to obtain the cement polymerization rate at 37°C (k 0 ) were as described in our previous work [30]. The PBS intake test involved measuring the mass gain of a circular cross-sectioned cement disc specimen cut from the end of an acceptable fatigue test specimen (nominal diameter and thickness of 8.50 mm and 3.00 mm, respectively) immersed in 15 mL 1X PBS solution at 37°± 1°C.…”

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confidence: 99%

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A Daptomycin-Xylitol-loaded Polymethylmethacrylate Bone Cement: How Much Xylitol Should Be Used?

Salehi

Parker

Lewis

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background The rate of release of an antibiotic from an antibiotic-loaded polymethylmethacrylate (PMMA) bone cement is low. This may be increased by adding a particulate poragen (eg, xylitol) to the cement powder. However, the appropriate poragen amount is unclear.Questions/purposes We explored the appropriate amount of xylitol to use in a PMMA bone cement loaded with daptomycin and xylitol. Methods We prepared four groups of cement, each comprising the same amount of daptomycin in the powder (1.36 g/40 g dry powder) but different amounts of xylitol (0, 0.7, 1.4, and 2.7 g); the xylitol mass ratio (X) (mass divided by mass of the final dry cement-daptomycin-xylitol mixture) ranged from 0 to 6.13 wt/wt%. Eight mechanical, antibiotic release, and bacterial inhibitory properties were determined using three to 22 specimens or replicates per test. We then used an optimization method to determine an appropriate value of X by (1) identifying the best-fit relationship between the value of each property and X, (2) defining a master objective function incorporating all of the best fits; and (3) determining the value of X at the maximum master objective function.

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Acrylic bone cements modified with poly(ethylene glycol)‐based biocompatible phase‐change materials

Król

Macherzyńska

Pielichowska

2016

J of Applied Polymer Sci

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The high polymerization temperature of acrylic bone cements used in hip replacement implantation may cause thermal necrosis of surrounding tissues. In order to reduce the polymerization temperature, acrylic bone cement has been modified with a biocompatible polymeric phase‐change material (PCM) based on poly(ethylene glycol) (PEG) of different molecular weights and stabilized with potato starch. Structural and morphological studies were performed, and the thermal and mechanical properties were investigated. The incorporation of PEG‐based PCM led to a decrease in the polymerization temperature of bone cement from 70 °C for unmodified cement to 58 °C for modified cement. Modified cement materials were stable in incubation tests, although acoustic analysis data revealed a decrease in propagation speed after incubation, which indicates formation of material defects (pores, cracks, voids, etc.) due to water activity. However, in the regeneration process, these defects can be filled by freshly grown bone tissue leading to better incorporation of bone cement replacements into tissue. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43898.

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Influence of strontia on various properties of Surgical Simplex® P acrylic bone cement and experimental variants

Cited by 19 publications

References 40 publications

Effects of ingredients on thermal and mechanical properties of acrylic bone cements

Effects of ingredients on thermal and mechanical properties of acrylic bone cements

A Daptomycin-Xylitol-loaded Polymethylmethacrylate Bone Cement: How Much Xylitol Should Be Used?

Acrylic bone cements modified with poly(ethylene glycol)‐based biocompatible phase‐change materials

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