Influence of cadmium loading on the state of the antioxidant system in the organism of bulls

Gutyj, B. V.; Mursjka, S D; Hufrij, D F; Hariv, I.; Levkivska, N D; Nazaruk, N. V.; Haydyuk, M B; Priyma, O B; Bilyk, Oksana; Guta, Z. A.

doi:10.15421/011611

Cited by 21 publications

(21 citation statements)

References 6 publications

(7 reference statements)

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“…It is established that under the influence of cadmium chloride at a dose of 0.04 mg/kg per body weight happens a decrease in enzyme activity, compared to control value, namely, on the tenth day -4.9%, on the fifteenth day -11, 7%, on the twenty-fifth day -12.2 %, on the thirtieth day -8%. The most significant antioxidant in glutathione system of the antioxidant protection is glutathione that performs many functions in animals' organism, one of which is to protect against free radicals, to support the functions of membranes, the participation in the metabolism of xenobiotics and the impact on the activity of enzymes (Ferreira et al, 1999;Bielenichev et al, 2002;Gutyj et al, 2016). Glutathione has a direct antioxidant effect.…”

Section: Resultsmentioning

confidence: 99%

Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load

Gutyj¹,

Stybel²,

Darmohray³

et al. 2017

Ukr J Ecol

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The results of studies of the effect of Cadmium influence on the state of the enzyme and nonenzyme system of antioxidant protection of young cattle organism, namely on the activity of superoxide dismutase, catalase, glutathione peroxidase, level of reduced glutathione, Selenium, vitamins A and E. It was determined that the feeding of young bulls with cadmium chloride in a dose of 0.04 mg / kg of body weight contributed to a decrease both, enzyme and non enzyme level of the system of antioxidant protection (superoxide dismutase by 22%, catalase -by 12%, renewed glutathione by 11%, glutathione peroxidase by 22 %, Selenium -by 18%, vitamin A -by 23%, vitamin E -by 27%,). The lowest level of the antioxidant protection system in the blood of young cattle was set at the sixteenth and twenty-fourth day of the experiment, which is due to the increased activation of lipoperoxidation processes and a disturbance of the balance between the activity of the antioxidant system and the intensity of peroxidation of lipids. The toxic effect of Cadmium contributes to the change in the stationary concentrations of the radical metabolites O2, ˙OH, NO2, which, in their turn, initiate the processes of peroxide oxidation of lipids, indicating an increase in the level of diene conjugates and malonic dialdehyde. The highest level of intermediate and final products of peroxid oxidation of lipids in the blood of young cattle was determined on the thirtieth day of the experiment, while comparing with the control group, they increased by 31 and 27%, respectively.

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Section: Resultsmentioning

confidence: 99%

Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load

Gutyj¹,

Stybel²,

Darmohray³

et al. 2017

Ukr J Ecol

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“…Протеїни крові тварин, перебуваючи у тісному функціональному зв'язку з білками різних тканин, віддзеркалюють ті зміни, які настають у тканинах і органах організму за розладів у них процесів метаболізму, спричинених патологічними чинниками (Cherkashina & Petrenko, 2006;Khariv et al, 2016;Hariv & Gutyj, 2016). Саме тому рівень загального протеїну і його фракцій у крові бугайців за експериментального кадмієвого токсикозу, відображає протеїнсентизувальну функцію печінки та ефективність проведеного лікування.…”

Section: результати та їх обговоренняunclassified

Protein synthesize function of bulls liver at experimental chronic cadmium toxicity

Lavryshyn

Gutyj

2019

SMLNUVMB

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The article presents the results of studies on the influence of cadmium load on the body of young cattle. The adverse effect of Cadmium on the liver causes a wide range of pathological changes at various levels of its organization. The purpose of the work was to investigate protein synthesize function on the liver of bulls for experimental chronic cadmium toxicity. The research was carried out on the basis of a farm at the village Ivanivtsi, Zhydachiv district of Lviv region, on 10 bulls of six months old, Ukrainian black-and-white milk breed, which were formed in 2 groups of 5 animals in each: control and experimental. Bulls of the control group were in the usual diet. Bulls of the experimental group were fed with forage with cadmium chloride at a dose of 0.04 mg/kg body weight of the animal. The research lasted for 30 days. Protein synthesize function of the liver was determined by the level of serum total protein and protein fractions. It was established that when feeding cows with feed of cadmium chloride in a dose of 0.04 mg/kg of body weight of an animal for 30 days in animals suppressed protein synthesize function of the liver, which manifests itself by lowering the total protein of blood. It reached the lowest level at the 20th day of the experiment, where, accordingly, it fluctuated within the limits of 61.9 ± 1.14 g/l. Reducing the level of total protein in the blood of the bulls of the experimental group under cadmium loading was due to lowering the level of albumin. At day 20 of the experiment, the level of albumin in the blood of animals in the experimental group decreased by 16.5%. On the background of general hypoproteinemia there is a significant imbalance between albumins and globulins in serum of diseased animals. It was established that the level of globulins increased in the blood of Bulls, which were under cadmium load. Increasing the level of globulins in blood serum of bulls reflects the intensity of inflammatory processes in their body for cadmium loading.

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“…Нагромадження їх у тканинах і органах сільськогосподарських тварин негативно впливає на імунологічний статус, ферментні системи, репродуктивну функцію організму, термін господарського використання. Внаслідок цього наприкінці ХХ і на початку ХХІ століття відбувається значне погіршення стану здоров'я і збільшується кількість захворювань (Butsiak & Kravtsiv, 2003;Salvatori et al, 2004;Kravtsiv et al, 2004;Kravtsiv et al, 2009;Gutyj, 2015;Hradovych et al, 2016;Hutyi et al, 2016;Vishchur et al, 2016;Khariv et al, 2016;Gutyj et al, 2017;Gutyj et al, 2019).…”

Section: вступunclassified

Dynamics of changes in protein metabolism rates in cows depending on the season of the year and the location of the farm

Vus

Kozenko

2019

SMLNUVMB

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Vus, U.M., & Kozenko, O.V. (2019). Dynamics of changes in protein metabolism rates in cows depending on the season of the year and the location of the farm. Scientific MessengerProtein metabolism in animals is perhaps the most informative indicator of anthropogenic environmental pollution, because it provides an opportunity to characterize metabolic processes in the body. They are of the utmost importance for the structure and function of all cells, tissues and organs. Proteins reflect the state of the organism, as well as those changes that occur in it under the influence of internal and external factors. We studied the dynamics of changes in indicators in protein metabolism in cows depending on the season of the year and the location of a farm. The research was carried out in two farms of the Lviv region: the Danylo Halytskyj LLC, near the State Mining and Chemical Enterprise "Sirka", and FE "Lelyk" of Zhovkva district, in spring, summer, autumn and winter periods of keeping. The object of research was the blood of 20 cows of Ukrainian Black-Spotted breed. According to the results of the research, a reduction in total protein, relative to the physiological norm of 0.45 g/l. in spring, and by 0.64 g/l in the summer, dysproteinemia, a high level of gamma globulin fraction (50.30%) in cows from the Danylo Halytskyj farm, located in the zone of influence of the State Chemical Medicine Plant "Sirka". In animals FE Lelyk, located in the conventionally clean zone, this indicator was significantly higher, and was 76.14 g/l in spring, and 78.17 g/l in summer, and also in animals of this farm dysproteinemia was not observed. In the autumn, at the end of the summer grazing period of the keeping, the index of total protein tended to decrease in the animals of the Danylo Halytsky's Ltd., and in winter it was normalized and invested in the limits of the physiological norm. Albumin fraction of protein in this group of animals, throughout the search period, had a tendency to increase. In the cows of the FE "Lelyk", the indices of protein metabolism were within the limits of the physiological norm in all periods of research, with the inherent fluctuations in the season of the year. The obtained results due to the content of total protein and protein fractions in the plasma of blood of cows kept in territories with different ecological status indicate that the effect of the activity of the State Chemical Medicine Plant "Sirka" is sufficiently strong on the organism of animals.Динаміка змін показників білкового обміну в корів залежно від сезону року та території розташування господарства У.М. Вус, О.В. Козенко Львівський національний університет ветеринарної медицини та біотехнологій імені С.З. Ґжицького, м. Львів, Україна Білковий обмін у тварин є чи не найбільш інформативним показником при техногенному забрудненні середовища, оскільки дає можливість охарактеризувати обмінні процеси в організмі. Вони мають винятково важливе значення для будови та функціонування всіх клітин, тканин і систем органів. Білки відображають стан ор...

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Influence of cadmium loading on the state of the antioxidant system in the organism of bulls

Cited by 21 publications

References 6 publications

Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load

Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load

Protein synthesize function of bulls liver at experimental chronic cadmium toxicity

Dynamics of changes in protein metabolism rates in cows depending on the season of the year and the location of the farm

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