Influence of Bushen Tiaochong Cycle Therapy on Th1/Th2 Deviation, Sex Hormone Level, and Pregnancy Outcome of Alloimmune Recurrent Spontaneous Abortion

Abstract

Objective. To analyze the influence of Bushen Tiaochong cycle therapy on Th1/Th2 deviation, sex hormone level, and pregnancy outcome of alloimmune recurrent spontaneous abortion (RSA). Methods. From August 2018 to April 2020, 130 patients with alloimmune RSA who met the inclusion criteria were randomly divided into the control group (n = 65) and the study group (n = 65). The former received lymphocyte immunotherapy (LIT), and the latter received Bushen Tiaochong cycle therapy on the basis of LIT. The treatment ended at 12 w of pregnancy. The total score of traditional Chinese medicine (TCM) syndromes, Th1 cytokine (IL-2), Th2 cytokine (IL-10), and related hormones (chorionic gonadotropin (hCG) and progesterone (P)) were compared between the two groups before and after treatment. The positive rate of blocking antibody (BA), pregnancy success rate, and preterm birth rate were counted. Result. After treatment, the total score of TCM syndromes, IL-2 level, and Th1/Th2 ratio in the two groups decreased significantly, while the levels of IL-10, hCG, and P increased significantly, and the study group improved significantly compared with the control group ( P < 0.05 ). The positive rate of BA and pregnancy success rate in the study group were higher than those in the control group ( P < 0.05 ). There was no significant difference in the preterm birth rate between the two groups ( P > 0.05 ). Conclusion. On the basis of routine western medicine treatment, a combined application of Bushen Tiaochong cycle therapy can significantly improve the Th1/Th2 deviation, serum sex hormone level, and pregnancy outcome in patients with alloimmune RSA.

The Prevalence of Abnormally Increasing Proportion of INF-γ/IL-4 in Peripheral Blood Among Patients with Unexplained Recurrent Spontaneous Abortion

“…In immunotherapy, the ratio of IFN-γ/IL-4, TNF-α/IL-4 and IL-2/IL-4 can be used as predictors of pregnancy establishment 20 . IL-2 /IL-10 and IFN-γ/IL-10 not only evaluate the pregnancy outcome of recurrent spontaneous abortion 21 , but also have evaluation significance for immunotherapy of patients with recurrent spontaneous abortion 22 .…”

Efficacy and safety of Gushen Antai Pills combined with dydrogesterone in the treatment of threatened miscarriage: a systematic review and meta-analysis

“…Evidence clarifying the effectiveness of GAP for TM can be identified in modern pharmacological studies. Holistically, pharmacological researches indicated that GAP benefited TM potentially through multiple mechanisms including enhance vascular function, improve immune activity, and regulate ovarian endocrine function, etc (Wang et al, 2021;Chen et al, 2022). In addition, modern pharmacological researches have pointed that baicalein, flavanone, norwogonin, rhynchophylline, polysaccharides, methoxyflavone, acacetin, anthraquinone glycosides and triterpenoid saponins are the main active components in GAP, which can improve blood circulation and placental blood supply, regulate disordered cellular immunity and humoral immunity, and improve endocrine dysfunction (Cao et al, 2020;Dang et al, 2022).…”

Editorial: Veterinary Reproductive Immunology

“…The proposal of an immunotropic hypothesis ( 51 ) elicited new and exciting concepts to the field of reproductive immunology [( 52 , 53 ), reviewed in ( 54 , 55 )] and elicited controversy ( 56 – 58 ) on the importance of the adaptive immune system in gestation maintenance. The initial concept of a Th1/Th2 balance required for successful gestation further evolved toward the concept of a balance between regulatory T cells (T-reg) ( 59 ) and T-reg/Th17 cells being critical for successful pregnancies ( 60 , 61 ).…”