Editorial: Veterinary Reproductive Immunology

Skarżyński, Dariusz; Bazer, Fuller W.; Maldonado-Estrada, Juan G

doi:10.3389/fvets.2021.823169

Cited by 1 publication

(1 citation statement)

References 76 publications

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“…During pregnancy, various immune effectors participate in the establishment of maternal tolerance toward the semi-allogeneic fetus, which set up a favorable humoral immunity [ 8 ]. In addition, some modulators of the maternal–fetal interface and humoral immune components play key roles in maintaining normal pregnancy in sheep [ 9 ]. Interferon-tau (IFNT) exerts paracrine and endocrine actions to inhibit luteolytic pulses of prostaglandin (PG) F2α and maintain corpus luteum function in ruminants, which modulate the innate immune events to avoid allogenic conceptus rejection from females during early gestation [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Early Pregnancy Modulates Expression of the Nod-like Receptor Family in Lymph Nodes of Ewes

Zhao

Cao

et al. 2022

Animals

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NOD receptors (NLRs) mediate adaptive immune responses and immune tolerance. Nevertheless, it is not clear if gestation modulates the NLR signaling pathway in lymph nodes of ewes. In this study, lymph nodes of ewes were collected at day 16 of the estrous cycle, and at days 13, 16 and 25 of gestation (n = 6 for each group). RT-qPCR, Western blot and immunohistochemistry analysis were used to analyze the expression of the NLR family, including NOD1, NOD2, CIITA, NAIP, NLRP1, NLRP3 and NLRP7. The data showed that early gestation enhanced expression of NOD1, CIITA, NLRP1, NLRP3 and NLRP7 mRNA, as well as proteins at day 16 of gestation, and the expression levels of NOD2, CIITA, NLRP1 and NLRP7 were higher at days 13 and 25 of gestation than day 16 of the estrous cycle. However, NOD1 expression was lower on days 13 and 25 of gestation compared to day 16 of the estrous cycle, and early gestation suppressed NAIP expression. In summary, early pregnancy modulated expression of the NLR family in ovine lymph nodes, which participates in immune regulation, and this modulation may be necessary for pregnancy establishment in ewes.

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Section: Introductionmentioning

confidence: 99%