Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

Cianciulli, Antonia; Calvello, Rosa; Ruggiero, Melania; Panaro, Maria Antonietta

doi:10.3390/molecules27020341

Cited by 31 publications

(17 citation statements)

References 167 publications

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“…Inflammaging is associated with many age‐related disorders, including geriatric depression, probably induced by pronounced and prolonged immune responses. 43 , 44 The imbalance of many endogenous proinflammatory and anti‐inflammatory chemicals is associated with mental disorders. For example, benzenebutanoic acid ameliorates lipopolysaccharide‐induced anxiety and depressive‐like behavior by reducing oxidation stress and the neuroinflammatory cascade.…”

Section: Discussionmentioning

confidence: 99%

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Systematic metabolic characterization of mental disorders reveals age‐related metabolic disturbances as potential risk factors for depression in older adults

Liu

Zhao

et al. 2022

MedComm

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Mental disorders are associated with dysregulated metabolism, but comprehensive investigations of their metabolic similarities and differences and their clinical relevance are few. Here, based on the plasma metabolome and lipidome of subcohort1, comprising 100 healthy participants, 55 cases with anxiety, 52 persons with depression, and 41 individuals with comorbidity, which are from WCHAT, a perspective cohort study of community‐dwelling older adults aged over 50, multiple metabolites as potential risk factors of mental disorders were identified. Furthermore, participants with mental illnesses were classified into three subtypes (S1, S2, and S3) by unsupervised classification with lipidomic data. Among them, S1 showed higher triacylglycerol and lower sphingomyelin, while S2 displayed opposite features. The metabolic profile of S3 was like that of the normal group. Compared with S3, individuals in S1 and S2 had worse quality of life, and suffered more from sleep and cognitive disorders. Notably, an assessment of 6,467 individuals from the WCHAT showed an age‐related increase in the incidence of depression. Seventeen depression‐related metabolites were significantly correlated with age, which were validated in an independent subcohort2. Collectively, this work highlights the clinical relevance of metabolic perturbation in mental disorders, and age‐related metabolic disturbances may be a bridge‐linking aging and depressive.

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Section: Discussionmentioning

confidence: 99%

“…Inflammaging is associated with many age‐related disorders, including geriatric depression, probably induced by pronounced and prolonged immune responses 43,44 . The imbalance of many endogenous proinflammatory and anti‐inflammatory chemicals is associated with mental disorders.…”

Section: Discussionmentioning

confidence: 99%

Systematic metabolic characterization of mental disorders reveals age‐related metabolic disturbances as potential risk factors for depression in older adults

Liu

Zhao

et al. 2022

MedComm

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“…Other candidate drugs include NR and NMN that are NAD+ precursor supplements, and non-steroidal anti-inflammatory drugs (NSAIDs), which can inhibit proinflammatory signaling pathways to reduce inflammation and finally exert an anti-ageing effect (77,97,98).…”

Section: Other Drugsmentioning

confidence: 99%

Cellular senescence of renal tubular epithelial cells in renal fibrosis

Zhang

et al. 2023

Front. Endocrinol.

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Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the pathogenesis of which is still unclear. Renal tubulointerstitial lesions have been identified as a key pathological hallmark of RF pathology. Renal tubular epithelial cells are the resident cells of the tubulointerstitium and play an important role in kidney recovery versus renal fibrosis following injury. Studies in recent years have shown that senescence of renal tubular epithelial cells can accelerate the progression of renal fibrosis. Oxidative stress(OS), telomere attrition and DNA damage are the major causes of renal tubular epithelial cell senescence. Current interventions and therapeutic strategies for cellular senescence include calorie restriction and routine exercise, Klotho, senolytics, senostatics, and other related drugs. This paper provides an overview of the mechanisms and the key signaling pathways including Wnt/β-catenin/RAS, Nrf2/ARE and STAT-3/NF-κB pathway involved in renal tubular epithelial cell senescence in RF and therapies targeting renal tubular epithelial cell senescence future therapeutic potential for RF patients. These findings may offer promise for the further treatment of RF and CKD.

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“…Some factors—such as genetic background, environmental factors, a possible initiating insult and age—can work together to activate microglial cells that are so entangled in the complex neuroinflammatory pathway [ 26 , 27 ]. All of these variable factors can cause inflammatory reactions, which begin by intracellular signaling cascades shortly after cellular injury and tissue damage.…”

Section: Neuroinflammation Neurodegeneration and Caffeinementioning

confidence: 99%

Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?

Ruggiero

Calvello

Porro

et al. 2022

IJMS

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In recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. In this review, we summarize the latest research about the potential effects of caffeine in neurodegenerative disorders prevention and discuss the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time.

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Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

Cited by 31 publications

References 167 publications

Systematic metabolic characterization of mental disorders reveals age‐related metabolic disturbances as potential risk factors for depression in older adults

Systematic metabolic characterization of mental disorders reveals age‐related metabolic disturbances as potential risk factors for depression in older adults

Cellular senescence of renal tubular epithelial cells in renal fibrosis

Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?

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