2023
DOI: 10.3389/fendo.2023.1085605
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Abstract: Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the pathogenesis of which is still unclear. Renal tubulointerstitial lesions have been identified as a key pathological hallmark of RF pathology. Renal tubular epithelial cells are the resident cells of the tubulointerstitium and play an important role in kidney recovery versus renal fibrosis following injury. Studies in recent years have… Show more

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Cited by 4 publications
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“…Upregulation of NRF2 has been suggested as a mechanism for reduced cellular senescence in models of diseases such as osteoporosis [ 180 ], age-related macular degeneration [ 181 ], age-related cognitive decline [ 182 ] and renal fibrosis [ 183 ]. Recently, Liu et al described how NRF2 is activated during DOX-induced senescence in two human cancer cell lines and in vivo by an accumulation of the oncogene iASPP (Inhibitor of Apoptosis Stimulating Protein of P53), which binds and inhibits KEAP1 [ 184 , 185 ].…”
Section: Drug-induced Cardiotoxicity and The Role Of Nrf2mentioning
confidence: 99%
“…Upregulation of NRF2 has been suggested as a mechanism for reduced cellular senescence in models of diseases such as osteoporosis [ 180 ], age-related macular degeneration [ 181 ], age-related cognitive decline [ 182 ] and renal fibrosis [ 183 ]. Recently, Liu et al described how NRF2 is activated during DOX-induced senescence in two human cancer cell lines and in vivo by an accumulation of the oncogene iASPP (Inhibitor of Apoptosis Stimulating Protein of P53), which binds and inhibits KEAP1 [ 184 , 185 ].…”
Section: Drug-induced Cardiotoxicity and The Role Of Nrf2mentioning
confidence: 99%