Targeting tumor suppressor p53 for organ fibrosis therapy
Yi-Ni Bao,
Qiao Yang,
Xin-Lei Shen
et al.
Abstract:Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor suppressor p53 (p53), known for its regulatory roles in cell proliferation, apoptosis, aging, and metabolism across diverse tissues, appears to play a pivotal role in aggravating biological processes such as epithelial-mesenchymal transition (EMT), cell apoptosis, and cell senescence. These processes are closely intertwined with the pathoge… Show more
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