Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation

Geng, Xinwei; Wang, Xiaohui; Luo, Man; Xing, Mingzhao; Wu, Yangjie; Wen, Li; Chen, Zhihua; Shen, Huahao; Ying, Songmin

doi:10.18632/aging.101477

Cited by 15 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chronic obstructive pulmonary disease (COPD) and asthma are the two most common respiratory disorders, and they constitute chronic non-specific lung diseases (CNSLD) [1]. COPD and asthma share many phenotype similarities, such as airflow limitation, breathlessness, dyspnea, coughing, wheezing and chronic inflammation [2,3]. Evidence is mounting suggesting that COPD and asthma are complex multifactorial diseases, involving many environmental and genetic components [4,5].…”

Section: Introductionmentioning

confidence: 99%

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Niu

et al. 2019

Aging

View full text Add to dashboard Cite

Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary disease (COPD) and asthma in northern Han Chinese. Genotypes were determined in 105 COPD patients, 242 asthma patients and 527 controls. In single-locus analysis, there was significant difference in the genotype distributions of rs1800624 between COPD patients and controls ( p =0.022), and the genotype and allele distributions of rs1800625 differed significantly ( p =0.040 and 0.016) between asthma patients and controls. Haplotype analysis revealed that haplotype T-A-G-T (allele order: rs1800625, rs1800624, rs2070600, rs184003) was significantly associated with a reduced COPD risk (OR=0.32, 95% CI: 0.06-0.60), and haplotype T-A-A-G was significantly associated with a reduced asthma risk (OR=0.19, 95% CI: 0.04-0.96). Further haplotype-phenotype analysis showed that high- and low-density lipoprotein cholesterol and blood urea nitrogen were significant mediators for COPD ( p sim =0.041, 0.043 and 0.030, respectively), and total cholesterol was a significant mediator for asthma ( p sim =0.009). Taken together, our findings indicate that RAGE gene is a promising candidate for COPD and asthma, and importantly both disorders are genetically heterogeneous.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Niu

et al. 2019

Aging

View full text Add to dashboard Cite

show abstract

“…NALP1 participates in the process of inflammation by activating the secretion of high mobility group protein B1 (HMGB1, UniProt: P09429). Bcl-2 is also associated with particulate matter-induced pneumonia and allergic airway inflammation by regulating the apoptosis process of inflammatory cells [ 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology

Xie

Yang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Reduning Injection (RDNI) is a traditional Chinese medicine formula indicated for the treatment of inflammatory diseases. However, the molecular mechanism of RDNI is unclear. The information of RDNI ingredients was collected from previous studies. Targets of them were obtained by data mining and molecular docking. The information of targets and related pathways was collected in UniProt and KEGG. Networks were constructed and analyzed by Cytoscape to identify key compounds, targets, and pathways. Data mining and molecular docking identified 11 compounds, 84 targets, and 201 pathways that are related to the anti-inflammatory activity of RDNI. Network analysis identified two key compounds (caffeic acid and ferulic acid), five key targets (Bcl-2, eNOS, PTGS2, PPARA, and MMPs), and four key pathways (estrogen signaling pathway, PI3K-AKT signaling pathway, cGMP-PKG signaling pathway, and calcium signaling pathway) which would play critical roles in the treatment of inflammatory diseases by RDNI. The cross-talks among pathways provided a deeper understanding of anti-inflammatory effect of RDNI. RDNI is capable of regulating multiple biological processes and treating inflammation at a systems level. Network pharmacology is a practical approach to explore the therapeutic mechanism of TCM for complex disease.

show abstract

“…[8，11] 。目前认为，多种因素如烟草暴露 [12] 、激素使用 [13] 、各种微生物感染 [14][15][16] 、颗粒吸入 [17][18] 、臭氧暴露 [19] 均可使哮喘模型气道中性粒细胞增多。…”

Section: 管在短期(4 周)还是长期(53 年)表型均稳定unclassified

The role of neutrophils in asthma

Chen¹,

Yu²,

Zhong³

et al. 2021

J Zhejiang Univ (Med Sci)

View full text Add to dashboard Cite

Bronchial asthma is a chronic respiratory disease，characterized by airway inflammation，airway hyperresponsiveness，reversible airway obstruction and airway remodeling，in which a variety of cells including airway inflammatory cells and structural cells are involved. Previous studies have shown that asthma is mainly driven by Th2 cytokines IL-4，IL-5，and IL-13，leading to airway eosinophil inflammation. With further research，however，it has been found that neutrophils are also closely related to asthma.

show abstract

Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation

Cited by 15 publications

References 23 publications

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Assessing the Anti-inflammatory Mechanism of Reduning Injection by Network Pharmacology

The role of neutrophils in asthma

Contact Info

Product

Resources

About