2019
DOI: 10.18632/aging.101975
|View full text |Cite
|
Sign up to set email alerts
|

Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese

Abstract: Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary disease (COPD) and asthma in northern Han Chinese. Genotypes were determined in 105 COPD patients, 242 asthma patients and 527 controls. In single-locus analysis, there was … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
8
1
1

Year Published

2020
2020
2024
2024

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 11 publications
(10 citation statements)
references
References 52 publications
(42 reference statements)
0
8
1
1
Order By: Relevance
“…Healthy controls were enrolled for the study in accordance with previously reported criteria 13 : (i) they had not been diagnosed with COPD, asthma or any other respiratory disease and (ii) they had no history of respiratory allergic diseases or any other respiratory symptom. Spirometry without bronchodilation was performed for the controls.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…Healthy controls were enrolled for the study in accordance with previously reported criteria 13 : (i) they had not been diagnosed with COPD, asthma or any other respiratory disease and (ii) they had no history of respiratory allergic diseases or any other respiratory symptom. Spirometry without bronchodilation was performed for the controls.…”
Section: Methodsmentioning
confidence: 99%
“…Individuals were excluded from the study in accordance with previously reported criteria 13 : (i) they had been diagnosed with cancer within the last 5 years,; (ii) they had experienced venous thromboembolism; (iii) they had been immobilized for > 3 days; (iv) they had a suspected acute inflammatory or infectious disease; (v) they had received anticoagulant therapy; (vi) they had smoked with an abstinence of only < 6 months; (vii) they were diagnosed with diabetes mellitus, heart failure, chronic renal failure or liver disease at the time; (viii) they were pregnant or under hormone‐replacement therapy; or (ix) they had a history of stroke or acute coronary syndrome.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…However, the association of rs2070600 with asthma risk remains unclear and requires more extensive investigation to clarify any association. 72,73 Although RAGE is most abundantly expressed in type 1 alveolar epithelial cells (AEC) 8 it is also expressed in a number of structural and immune cells involved in asthma pathogenesis. This includes, airway epithelia, 74 airway smooth muscle cells (ASMC), 75 lung endothelia, 76 lung fibroblasts, 77 alveolar macrophages, 78 eosinophils, 79 neutrophils, 80 mast cells, 81 lymphocytes 82 and ILC2s.…”
Section: R Ag E E Xpre Ss I On In a S Thmamentioning
confidence: 99%
“…An increase in RAGE‐signaling likely contributes to augmented inflammation, which could exacerbate airway obstruction and disease severity. However, the association of rs2070600 with asthma risk remains unclear and requires more extensive investigation to clarify any association 72,73 . Although RAGE is most abundantly expressed in type 1 alveolar epithelial cells (AEC) 8 it is also expressed in a number of structural and immune cells involved in asthma pathogenesis.…”
Section: Rage Expression In Asthmamentioning
confidence: 99%