2022
DOI: 10.1002/iid3.711
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The role of HMGB1/RAGE/TLR4 signaling pathways in cigarette smoke‐induced inflammation in chronic obstructive pulmonary disease

Abstract: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with irreversible and continuous progression. It has become the fifth most burdensome disease and the third most deadly disease globally. Therefore, the prevention and treatment of COPD are urgent, and it is also important to clarify the pathogenesis of it. Smoking is the main and most common risk factor for COPD. Cigarette smoke (CS) can cause lung inflammation and other pathological mechanisms in the airways and lung tissue.… Show more

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Cited by 13 publications
(1 citation statement)
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“…CS-induced macrophage dysfunction leads to in ammation and resultant destruction/remodeling which increases susceptibility to development of CS-induced lung diseases 15 . CS contributes to the development of lung cancer with both pro-in ammatory and immunosuppressive effects 16,17 . CS was reported to induce ADAM12 + CTLA4 + Tregs (a unique subset of tumor-speci c activated Tregs) which interact with exhausted T cells in the tumor immune environment of lung cancer 18 .…”
Section: Introductionmentioning
confidence: 99%
“…CS-induced macrophage dysfunction leads to in ammation and resultant destruction/remodeling which increases susceptibility to development of CS-induced lung diseases 15 . CS contributes to the development of lung cancer with both pro-in ammatory and immunosuppressive effects 16,17 . CS was reported to induce ADAM12 + CTLA4 + Tregs (a unique subset of tumor-speci c activated Tregs) which interact with exhausted T cells in the tumor immune environment of lung cancer 18 .…”
Section: Introductionmentioning
confidence: 99%