Induction of cutaneous delayed hypersensitivity reactions in mice sensitized with intragastrically administered hapten: activation of Langerhans cells in the sensitization and elicitation phases

Fujita, Naoko; Kobayashi, Hiromi; Tsuruta, Daisuke; Sakaguchi, Ikuo; Yamanaka, K; Kutsuna, Hiroshi; Teramae, Hiroyuki; Mizuno, Nobuyuki; Ikeda, Naoki; Kato, Yasuhiro; Minamino, Miki; Kaneda, Kenji; Ishii, Masamitsu

doi:10.1046/j.1365-2133.2003.05592.x

Cited by 3 publications

(1 citation statement)

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“…Digestive tract diseases have become a more common problem these days and are often blamed on lifestyle choices and poor eating habits. It has been reported that delayed cutaneous hypersensitivity reactions are induced by intragastrically administered hapten in mice [1] . It has also been asserted that ulcerative colitis is closely associated with atopic dermatitis [2] .…”

Section: Introductionmentioning

confidence: 99%

Pyeongwee-San extract (KMP6): a new anti-allergic effect

Han

Kim

Jeong

2011

Journal of Pharmacy and Pharmacology

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Section: Introductionmentioning

confidence: 99%

Pyeongwee-San extract (KMP6): a new anti-allergic effect

Han

Kim

Jeong

2011

Journal of Pharmacy and Pharmacology

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Immobilization stress suppresses cutaneous delayed‐type hypersensitivity reaction induced by gastrointestinal sensitization in mice: association with Langerhans cell of the forestomach

et al. 2008

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Psychological stress (PS) has various influences on allergic diseases. Although gastrointestinal sensitization induces hypersensitivity reactions in the skin, such as urticaria and dermatitis, due to food or drug allergy, the effect of PS on the gastrointestinal sensitization phase remains unclear. We administered 2,4,6‐trinitrochlorobenzene (TNCB) to BALB/c mice intragastrically (gastrointestinal sensitization). After 4 days, we elicited a cutaneous delayed‐type hypersensitivity (DTH) reaction by applying TNCB to the ear. We examined the effects of immobilization stress (IS) before gastrointestinal sensitization and elicitation on the cutaneous DTH (CDTH) by measurement of the thickness of the swollen ear, morphological changes and the number of Ia molecule‐positive Langerhans cells (Ia + LC) in the forestomach, and serum corticosterone (CORT) concentration. In addition, we studied the effect of pre‐administration of a glucocorticoid receptor antagonist (RU486). CDTH was suppressed significantly with application of IS for more than 6 h prior to gastrointestinal sensitization. Simultaneously, Ia + LC became smaller and round in shape and decreased in number. The serum CORT concentration doubled following IS for more than 2 h, and these changes were suppressed by pre‐administration of RU486. The results indicate that IS suppresses gastrointestinal sensitization, probably in association with suppression of the antigen‐presenting function of the Ia + LC by elevation of steroid hormones. Copyright © 2008 John Wiley & Sons, Ltd.

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Evaluation on Efficacy of Modern Medicine Ketotifen Using Traditional Delivery Science Acupuncture in Allergic Animal Models

Jeong

Jung

Kim

et al. 2014

Journal of Drug Delivery Science and Technology

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Induction of cutaneous delayed hypersensitivity reactions in mice sensitized with intragastrically administered hapten: activation of Langerhans cells in the sensitization and elicitation phases

Abstract: The present study demonstrated that gastric LCs and epidermal LCs were activated in vivo in the sensitization and elicitation phases, respectively, of cutaneous DTH reactions in orally sensitized mice.

Cited by 3 publications

References 31 publications

Pyeongwee-San extract (KMP6): a new anti-allergic effect

Pyeongwee-San extract (KMP6): a new anti-allergic effect

Immobilization stress suppresses cutaneous delayed‐type hypersensitivity reaction induced by gastrointestinal sensitization in mice: association with Langerhans cell of the forestomach

Evaluation on Efficacy of Modern Medicine Ketotifen Using Traditional Delivery Science Acupuncture in Allergic Animal Models

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