Evaluation on Efficacy of Modern Medicine Ketotifen Using Traditional Delivery Science Acupuncture in Allergic Animal Models

Jeong, Hyun‐Ja; Jung, Jaehun; Kim, Mingi; Kim, Hyung-Min

doi:10.1016/s1773-2247(14)50038-x

Cited by 3 publications

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“…However, ketotifen is a compound with strong anti-anaphylactic and antihistaminic properties both in experimental animals and humans [19]. Ketotifen not only blocks H 1 receptors and stabilizes mast cells, it also reduces intracellular calcium levels in activated mast cells [20,21]. In the present study, we did not note an effect of Buk music on mast cell stabilization and intracellular calcium level.…”

Section: Discussioncontrasting

confidence: 51%

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

Kim

Nam

et al. 2015

Int Arch Allergy Immunol

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Background: Anaphylaxis is associated with systemic vasodilation that causes low blood pressure and induces hypoxic brain damage. The sound of a Buk (Korean traditional drum) is similar to the human heart beat and affects blood pressure, heart rate, and the nervous system by increasing physiological excitation and sympathetic nervous system activity. So, this study focused on the effect of Buk music as a means of treating anaphylaxis. Methods: Mice were given an intraperitoneal injection of compound 48/80 (6.5 mg/kg, a mast cell degranulator). After compound 48/80 injection, mice were exposed to Buk music and white noise for 5 min in a sound isolation booth. The mortality rate was checked over the next 40 min. Levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in the serum and brain tissues were analyzed by Western blotting, quantitative real-time PCR, and ELISA methods. Results: Exposure to Buk music significantly reduced compound 48/80-induced mortality and histamine release, as well as HIF-1α and VEGF levels compared with the compound 48/80 group or compound 48/80 and white noise group. Buk music also reduced levels of tumor necrosis factor-α, and significantly increased estrogen receptor-β mRNA levels. Conclusion: These results indicate that Buk music has potential for the treatment of anaphylaxis.

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Section: Discussioncontrasting

confidence: 51%