Formulation, characterization and cytotoxicity evaluation of ketotifen-loaded nanostructured lipid carriers

Dolatabadi, Jafar Ezzati Nazhad; Azami, Aida; Mohammadi, Ali; Hamishehkar, Hamed; Panahi‐Azar, Vahid; Saadat, Yalda Rahbar; Saei, Amir Ata

doi:10.1016/j.jddst.2018.05.017

Cited by 21 publications

(7 citation statements)

References 30 publications

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“…Finally, to obtain a fine powder of EPI-loaded targeted SLNs, L-SLNs were lyophilized using a lyophilizer (ZibrusVaco 10-II-E; Germany). 4 …”

Section: Methodsmentioning

confidence: 99%

“…The cumulative percentage of EPI amount in dissolution vessel vs. time (hours) was plotted. 4,13 Cytotoxicity evaluation MTT test was used to evaluate the viability of the MCF-7 cells upon treatment with EPI loaded SLNs and L-SLNs. 96-well plates (Nalgene Nunc International, Ochester, NY) were used for seeding of cells and incubated to permit adequate adhesion.…”

Section: Epi Release From Slns and L-slnsmentioning

confidence: 99%

“…The use of nanosciences in nanomedicine and more specifically in the field of pharmaceutical science for innovation of drug nanocarriers in the management of disease as well as a cancer therapy is set to spread rapidly. [1][2][3][4][5] In this field, targeted drug delivery have been explored for nominal cancer therapy by exploration of several carriers and methods. [6][7][8] Solid lipid nanoparticles (SLNs) as cost-effective and significant drug carriers has been fabricated for liposomes replacement two decades ago.…”

Section: Introductionmentioning

confidence: 99%

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Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy

et al. 2020

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Purpose: Cancer is an example of the most important growing diseases in human society and scientists are trying to treat it without considerable side effects on patient's health. Solid lipids are colloidal nanoparticles that were used in drug delivery due to their several advantages. Methods: In this work, surface modified targeted solid lipid nanoparticles (SLNs) were fabricated by nano-homogenizer using tripalmitin glyceride and stearic acid as lipid constituents. The size of nanoparticles and morphological evaluations were surveyed using particle size analyzer, scanning electron microscopy; Fourier transforms infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Results: The particle size of 148.5 and appropriate polydispersity index were achieved for lipid nanoparticles with an entrapment efficiency of 86.1%. The FT-IR analysis confirmed the coupling of lysine to the free functional group of SLNs. DSC proved the conjugation of amino acid to the surface of carriers. The in vitro epirubicin (EPI) release test exhibited the further controlled release phenomenon for the lysine conjugated nanoparticles. The cytotoxicity assay showed lower IC50 of lysine conjugated SLNs of EPI on the investigated cell line. Conclusion: These studies showed that the fabricated targeted carrier has a very remarkable anticancer effect on breast cancer cell lines in comparison with pure drug.

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“…Finally, to obtain a fine powder of EPI-loaded targeted SLNs, L-SLNs were lyophilized using a lyophilizer (ZibrusVaco 10-II-E; Germany). 4 …”

Section: Methodsmentioning

confidence: 99%

Section: Epi Release From Slns and L-slnsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy

et al. 2020

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“…Since SLNs have limitations such as drug leakage through the matrix and reduced loading efficiency, a new generation of NLCs have been designed [33,40]. In these NLCs formulations, mixing solid lipids with small amounts of liquid lipids to induce rearrangements of the matrix structure increased their qualities while preserving the original benefits of SLNs [28,41]. SLNs have European Medicines Agency (EMA) and FDA approval and are commercially available for intravenous, dermal, and oral delivery [34].…”

Section: Lipid Nanomaterials In the Delivery Of Drugsmentioning

confidence: 99%

Nanomaterials in Pharmaceuticals

Foyez

2023

Emerging Applications of Nanomaterials

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Nanotechnology is a relatively new but fast-expanding field that uses nanoparticles as analytical tools or as a controlled delivery system for pharmaceuticals. The unique properties of nanomaterials, including thermodynamic, electrical, structural capabilities, and optical make them intriguing options for pharmaceuticals, which substantially impact drug quality. Pharmaceutical nanotechnology, with its nano-engineered tools, is now well-established for drug delivery, diagnostics, prognosis, and disorder therapy. It has the potential to improve materials and medical devices as well as help to introduce new technologies in areas where traditional technologies have reached their limits. The present review focuses on nanomaterials and their applications in pharmaceuticals.

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“…101 Therefore NLCs are categorized as second generation lipid based nano-drug carriers. [102][103][104][105][106] Dolatabadi et al 107 successfully prepared Ketotifen incorporated NLCs with enhanced systemic exposure and reduced cellular toxicity. Hot homogenization and ultrasonication method was used for NLCs preparation.…”

Section: Nano-structured Lipid Carriers (Nlcs)mentioning

confidence: 99%

Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement

Chaturvedi

Verma

Saharan³

2020

Adv Pharm Bull

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In the treatment of cancer, chemotherapy plays an important role though the efficacy of anticancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (P-gp) mediated drug efflux, and pre-systemic metabolism. These all factors cumulatively reduce drug exposure at the target site leading to multidrug resistance (MDR). Lipid based carriers systems has been explored to overcome solubility and permeability related issues of anti-cancer drugs. The lipid based formulations have also been reported to circumvent the effect of P-gp and CYP3A4. Further long chain triglycerides (LCT) has shown their ability to access Lymphatic route over Medium Chain Triglycerides, as the former has been extensively used for targeting anti-cancer drugs at proliferating cells through lymphatic route. Therefore this review tries to reflect the usefulness of lipid based drug carriers systems (viz. liposome, solid lipid nanoparticle, nano-lipid carriers, self-emulsifying, lipidic pro-drugs) in targeting lymphatic system and overcoming issues related to solubility and permeability of anti-cancer drugs. Moreover, we have also tried to reflect how critically lipid based carriers are important in maximizing therapeutic safety and efficacy of anti-cancer drugs.

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Formulation, characterization and cytotoxicity evaluation of ketotifen-loaded nanostructured lipid carriers

Cited by 21 publications

References 30 publications

Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy

Lysine Decorated Solid Lipid Nanoparticles of Epirubicin for Cancer Targeting and Therapy

Nanomaterials in Pharmaceuticals

Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement

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