Pyeongwee-San extract (KMP6): a new anti-allergic effect

Abstract

These results suggest that KMP6 may exert an anti-allergic effect through not only the inhibition of mast cell degranulation but also the inhibition of histamine synthesis.

Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

“…Additionally, increased histamine tissue levels in the hypothalamus and brainstem nuclei such as the vestibular nucleus and the dorsal vagal complex are considered the primary reason for induction of motion sickness [ 83 , 85 , 86 , 87 , 88 , 89 ]. Although, like rats, mice do not vomit, motion sickness experience evokes increased levels of histamine, histamine H 1 receptor mRNA, and H 1 receptor protein expression in their hypothalamus and brainstem, which can be significantly reduced by pretreatment with hesperidin [ 83 ], a bioflavonoid that inhibits the synthesis and release of histamine from mast cells [ 90 ]. Histamine H 1 receptor blockers such as dimenhydrinate and diphenhydramine are commonly used antiemetic agents against nausea and vomiting secondary to motion sickness [ 91 , 92 , 93 ].…”

β‐eudesmol suppresses allergic reactions via inhibiting mast cell degranulation

“…Atractylone, which is an active constituent of Atractylodes japonica and comprises 0.72 mg in 1 g of KMP6, regulated the mast cell‐mediated allergic reactions and allergic rhinitis symptoms . Furthermore, hesperidin, which is an active constituent of Citrus sunki and comprises 5.26 mg in 1 g of KMP6, ameliorated the mast cell‐mediated allergic reactions and allergic rhinitis symptoms . Glycyrrhizic acid, which is an active constituent of Glycyrrhiza uralensis and comprises 2.60 mg in 1 g of KMP6, inhibited atopic dermatitis‐like skin lesions .…”

“…Ketotifen was dissolved with DW and filtered through a 0.22 μm syringe filter. It has been previously reported that KMP6 suppresses allergic reactions at various concentrations ranging from 0.01 to 1 g/kg . In this study, the focus was the effect of β‐eudesmol; thus, the effects of β‐eudesmol were assessed at various doses and KMP6 was assessed at one dose (0.1 g/kg).…”

“…In this study, the focus was the effect of β‐eudesmol; thus, the effects of β‐eudesmol were assessed at various doses and KMP6 was assessed at one dose (0.1 g/kg). The dosage of KMP6 (0.1 g/kg) and ketotifen (2 mg/kg) was determined according to previous reports . β‐eudesmol, KMP6, and ketotifen were orally administered in a volume of 0.1 mL/10 g for mice…”

“…It has been reported that Pyeongwee‐San (KMP6), which has been used to treat digestive diseases in traditional Korean medicine, has a beneficial effect on allergic reactions and atopic dermatitis . Atractylodes japonica is the primary component of KMP6 and β‐eudesmol is a significant constituent of Atractylodes japonica .…”