Induction of apoptosis and antiangiogenesis effects of pinostrobin from Kaempferia pandurata Roxb against induction of fibrosarcoma mice results benzopiren

Abstract

Induction of apoptosis and antiangiogenesis effects of Pinostrobin from Kaempferia pandurata Roxb against Fibrosarkoma mice results benzopiren induction has been done. Examination or surgery begins taking tissue fibrosarcoma in mice infected and weigh fibrosarcoma obtained. Fibrosarcoma tissues were then stored in containers that have contained 10 % formalin. Weighing results showed that the concentration of pinostrobin oral 80 mg / kg can inhibit the growth of fibrosarcoma with a gram weight of 68.62 % and a cancer drug (control +) there is resistance 95.95 % compared to the negative control which is only given orally CMC-Na, this means pinostrobin potentially be developed as a cancer chemotherapy. 20 Adi Parwata et al. Furthermore done shooting patohistologi tissue fibrosarcoma with HE staining with a light microscope with 400x magnification. The results obtained showed many chromatin (polikromatin) which prove the damage caused by having fibrosarcoma cells. Immunohistochemical assay showed oral pinostrobin concentration 80 mg / kg body weight can increase the expression of p53 to apoptosis induction could take place and the decreased expression of VEGF angiogenesis which proves the existence of barriers.

The activity of bioactive compounds against several diseases by modulating autophagy

“…1d) is one of the most flavones found in fingerroot (Boesenbergia rotunda) and honey which is commonly potential as an antioxidant and contribute against several diseases (Fahey and Stephenson, 2002;Chahyadi et al, 2014;Patel et al, 2016;Atun et al, 2017;Jadaun et al, 2019). Even though there are few numbers of reports regarding pinostrobin, some are reported to have roles to some cancers, such as in breast cancer by binding with estrogen receptor and fibrosarcoma by upregulating the expression of p53 and decreasing activation of VEGF angiogenesis (Le Bail et al, 2000;Parwata et al, 2015). It also has a role as a neuroprotector against Alzheimer's Diseases (AD) by increasing the ratio of Bcl-2/Bax ratio in PC12 cells, leading to apoptosis (Xian et al, 2012).…”

Fingerroot (Boesenbergia pandurata) : A Prospective Anticancer Therapy

“…Pinostrobin has anti-angiogenesis activity and is able to induce apoptosis. According to Parwata, et al (2014), oral administration of pinostrobin may inhibit fibrosarcoma growth in benzopireninduced mice. In addition, pinostrobin is able to inhibit the path of bFGF and VEGF on the chorio alantois membrane of chicken embryos induced by basic fibroblast growth factor (Pratomo, et al, 2014).…”

Electronic and Structural Properties of 5-Hydroxy-7-Metoxyflavanone: A Theoretical Approach

“…However, the analysis of both structures shows that C6 and C8 exhibit slight differences in the net charges, suggesting that might have different reactivity, modulated by the rotation of the methoxy group, transforming the structure I in the II. In addition, in pinostrobin the polarity of the structure is reduced as a result of intra-molecular hydrogen bonding between the carbonyl group at C4 with a hydroxy group at C5 [41], producing a low water solubility. Our calculations show that the dipole moment of the structure II (5.42 D at MP2 level) is greater than the structure I (2.37 D at MP2 level), indicating that the structure II would be slightly more soluble in water than I.…”