Indomethacin, Reduced Retinal Sensitivity, and Corneal Deposits

Ocular Toxicity Due to Chloroquine and Hydroxychloroquine: Electrophysiological and Visual Function Correlates

“…Can other drugs used for the same therapeutic purposes lead to similar ERG alterations? In 1968, Burns [90] studied 31 patients with rheumatoid arthritis, treated with indomethacin (and not with CQ/HCQ). She found decreased ERG values in all cases.…”

Ocular Side Effects of Indomethacin

“…Burns [1968] reports an incidence of corneal involvement in 16% (6 of 34 Indocid-treated patients). In our cases we found corneal involve ment at 11% (2 of 18 patients).…”

“…The daily dose is up to 200 mg, usually about 100 mg Indomethacin is known to cause some general side effects such as gastro-intestinal irritation, light headcdness and dizziness, and to aggravate Parkinsonism, epilepsy and some psychic disturbances [Ellis, 1970]. Ocular side effects have been described either as corneal deposits or as pigment degeneration of the retina [Burns, 1966[Burns, , 1968H enkes, 1971]. Crews, in 1969, mentions that it might affect the retina, and Chapman [1966] reports the development of vitreous hemorrhages possibly due to the use of indomethacin.…”

Métodos diagnósticos para retinopatia induzida pelo difosfato de cloroquina nos portadores de lúpus eritematoso sistêmico

“…Sabe-se que alterações funcionais podem estar presentes nos pacientes com artrite reumatóide mesmo antes do uso dos antimalá-ricos (30) , o que também é questionado nos pacientes lúpicos. Deve-se considerar ainda que outras drogas utilizadas no tratamento destes pacientes também podem causar toxicidade retiniana e neuropatia óptica, como é o caso dos imunossupressores (31)(32) , o que pode ter contribuído para a alta prevalência da retinopatia neste grupo.…”