Increased Urinary Enzyme Excretion in Workers Exposed to Nephrotoxic Chemicals

Meyer, B. Robert; Fischbein, Alf; Rosenman, Kenneth D.; Lerman, Yehuda; Drayer, Dennis E.; Reidenberg, Marcus M.

doi:10.1016/s0022-5347(17)49077-x

Cited by 14 publications

(17 citation statements)

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“…This observa tion suggests that renal tubular dysfunction may occur after chronic low-level lead exposure, even the blood lead level is in the 'safe' or 'normal' range. Our results are also supported by previous studies [12,13] in occupational lead-exposed workers. In Meyer et al's [ 12] study, urinary excretion of NAG was utilized to evaluate the renal func tion of 29 workers who had been exposed to lead in the workplace for a long term.…”

Section: Discussionsupporting

confidence: 93%

“…Our results are also supported by previous studies [12,13] in occupational lead-exposed workers. In Meyer et al's [ 12] study, urinary excretion of NAG was utilized to evaluate the renal func tion of 29 workers who had been exposed to lead in the workplace for a long term. None of the persons had clini cally evident renal disease by history, none had hyperten sion, and all had normal findings on urinalysis.…”

Section: Discussionsupporting

confidence: 93%

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Urinary N-Acetyl-Glucosaminidase Excretion and Environmental Lead Exposure

et al. 1993

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To understand the relationship between chronic low-level lead exposure and renal function, residents living nearby a lead battery factory for more than 10 years were selected and entered in this cross-section study. The residents living in the 1 st village, within 500 m from the factory, were grouped in group 1; those in the 2nd village, within 1,000-1,500 m, in group 2, and those in the 3rd village, far from any lead-contaminated sources, in group 3. Twenty-four-hour urinary N-acetyl-glucosaminidase (NAG) was detected as early indicator of renal damage, and an ethylenediamine-tetraacetic acid mobilization test was performed to estimate total body lead burden of lead-exposed persons. Blood lead level (BLL) showed a significant difference among the three study groups. The further the distance between the group and the factory, the higher BLL. The results showed a significant high prevalence of abnormal urine NAG exretion in the chronic lead-exposed group, although BLL and body lead burden of these persons were within the ‘normal’ range. A significant correlation between body lead burden less than 200 µg and 24-hour urine NAG excretion and a dose-response relationship between them were found. These observations suggested that lead was the possible cause of abnormal renal tubular function in persons with chronic low-level lead exposure, but this effect became blunt when body lead burden was more than 200 µg. The possible explanation may be that high body lead burden from long-term exposure will deplete the kidney of NAG or render it insensitive to the effects of lead exposure. Whether urine NAG is an early indicator of lead nephropathy is still unconclusive, and long-term follow-up in our study is needed to detail these relations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Urinary N-Acetyl-Glucosaminidase Excretion and Environmental Lead Exposure

et al. 1993

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“…Tests for Detection (74,(135)(136)(137)(138)(139)(140). Verschoor et al (59), in a study of lead workers with blood lead levels below 60 pg/dl (2.89 pmol/l), found the excretion of NAG to be the most sensitive marker of renal tubular dysfunction.…”

Section: Lead Nephropathymentioning

confidence: 99%

Renal Effects of Environmental and Occupational Lead Exposure

Loghman‐Adham¹

1997

Environmental Health Perspectives

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“…In a US study [45], NAG levels were measured in five groups exposed to nephrotoxins (mercury, lead and sol vents). The three solvent-exposed groups included chem ical-plant employees working with mixed solvents, leather finishers who worked with vinyl coatings (ex posed to mixed solvents but at levels lower than the chemical workers) and analytical chemists working with compounds derived from hazardous waste (described as the lowest-exposed group).…”

Section: Cross-sectional Epidemiologic Studies: Subtle Markers Of Renmentioning

confidence: 99%

Solvent Nephrotoxicity in Humans and Experimental Animals

1990

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Evidence from human case reports, epidemiologic studies and animal experiments have suggested that exposure to organic solvents is associated with a wide spectrum of renal disorders, including tubular necrosis, interstitial disease, glomerulonephritis and neoplasia. This review summarizes what is known about solvent-induced renal damage in humans and experimental animals, with emphasis on hypothesized mechanisms by which this broad range of disorders may occur.

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Increased Urinary Enzyme Excretion in Workers Exposed to Nephrotoxic Chemicals

Cited by 14 publications

References 0 publications

Urinary N-Acetyl-Glucosaminidase Excretion and Environmental Lead Exposure

Urinary N-Acetyl-Glucosaminidase Excretion and Environmental Lead Exposure

Renal Effects of Environmental and Occupational Lead Exposure

Solvent Nephrotoxicity in Humans and Experimental Animals

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