Renal Effects of Environmental and Occupational Lead Exposure

Abstract

Environmentl and industrial lead exposurs coninue t pose major public health problems in children and in adults. Acute

Relationship between blood lead levels and renal function in lead battery workers

“…They suggested that those indicators were the most sensitive and useful for renal dysfunction investigation. (Endo et al 1990(Endo et al , 1993Chia et al 1995;Loghman-Adham 1997;Jung et al 1998). …”

“…Saturnine gout is a consequence of decreased tubule function (Zenz 1994). The development of gout appears to be a common feature of lead nephropathy (Loghman-Adham 1997).…”

“…The absorbed lead in the body is mainly excreted through the kidneys and, therefore, causes renal ultrastructural damage in the proximal tubules where two-thirds of the filtered load is re-absorbed (Zenz 1994;DeRoos 1997;Loghman-Adham 1997;Rodriguez 1997). Renal histological changes in chronic lead nephropathy are non-specific and typically associated with interstitial fibrosis, both hyperplasia and atrophy of the tubules, glomerular sclerosis.…”

“…Renal histological changes in chronic lead nephropathy are non-specific and typically associated with interstitial fibrosis, both hyperplasia and atrophy of the tubules, glomerular sclerosis. These toxic effects lead to progressive and irreversible renal failure (Goyer 1971;Nolan and Shaikh 1992;Loghman-Adham 1997). Because of damage to both glomeruli and proximal tubules, the glomerular filtration, renal clearance and tubular re-absorption are affected.…”

Aminoaciduria and glycosuria following severe childhood lead poisoning

“…An association between lead poisoning and renal disease in humans has been recognized for over a century [1,2]. Renal manifestations of acute lead poisoning include glycosuria, aminoaciduria, and phosphaturia, collectively representing the Fanconi syndrome [2±5].…”