Addition of chemotherapy to local definitive treatment has significantly increased the morbidity of treatment as well as the chance of initial tumor response and local control. A statistically significant improvement in survival was found for the simultaneous use of chemotherapy and local definitive treatment.

We previously isolated a cDNA clone encoding interferon consensus sequence-binding protein (ICSBP), a member of the interferon regulatory factor (IRF) (10,15,40,42,69,74). Recent genomic footprinting studies show that ISREs are constitutively occupied in vivo (19,56). IFN treatment leads to induction of multiple ISRE binding activities that differ in sensitivity to protein synthesis inhibitors (47, 74). One such IFN-inducible binding activity, ISGF3, is formed in the nucleus after translocation of preexisting components from the cytoplasm (45, 46). Inducible factor binding has been reported following virus induction of the IFN-13 gene as well (40,41).A number of laboratories have isolated cDNAs coding for proteins that bind to the ISRE. PRDI-BF1, a factor that binds to the virus-inducible element of the IFN-P gene, has been cloned by Keller and Maniatis (41

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