Increased blood fibrinolytic activity after physical exercise: Comparative study in individuals with different sporting activities and in patients after myocardial infarction taking part in a rehabilitation sports program

Speiser, Wolfgang; Langer, Werner; Pschaick, A; Selmayr, E.; Ibe, B.; Nowacki, P. E.; Müller‐Berghaus, Gert

doi:10.1016/0049-3848(88)90119-3

Cited by 90 publications

(35 citation statements)

References 30 publications

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“…2932 It is possible that the lower PAI-1 activity in physically active men compared with inactive men observed in the present study and by other investigators 26 is an important mechanism mediating the cardioprotective effect afforded by participation in regular physical activity. 33 Since thrombosis appears to be the immediate cause of most myocardial infarctions, 34 impaired fibrinolytic activity may play a crucial role in its pathology.…”

Section: Discussionmentioning

confidence: 55%

“…Although few studies have focused on the mechanisms involved, Stratton et al 22 contend that an increase in endothelial protein production probably does not explain the enhanced fibrinolytic activity observed in physically trained individuals because they did not observe a posttraining increase in other endothelial proteins. It has also been hypothesized that changes in PAI-1 activity may be mediated by the lipid-related changes that occur with habitual exercise, 26 evidenced by the correlation that has been found between triglycerides and PAL 27 Thus, many questions pertaining to the mechanisms involved in fibrinolytic changes with exercise are still unanswered; however, the present investigation was not designed to investigate potential mechanisms.…”

Section: Discussionmentioning

confidence: 93%

“…28 Elevated PAI-1 activity has been documented in survivors of myocardial infarction 26 ' 27 and individuals with coronary artery disease. 2932 It is possible that the lower PAI-1 activity in physically active men compared with inactive men observed in the present study and by other investigators 26 is an important mechanism mediating the cardioprotective effect afforded by participation in regular physical activity.…”

Section: Discussionmentioning

confidence: 99%

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Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men.

Szymanski

Pate

1994

Arterioscler Thromb

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The purposes of this study were to compare fibrinolytic responses to moderate intensity exercise in physically active and inactive men and during morning and evening exercise. Fourteen physically inactive men (mean age, 34.7±4.0 years) and 12 regularly active men (34.8±4.0 years) performed two exercise sessions, morning and evening, at 50% of maximal oxygen consumption. Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) activity were measured before and after exercise. Data were analyzed using a three-way ANOVA with repeated measures. TPA activity increased with exercise in both groups, although the active group demonstrated greater increases than the inactive group. Postexercise TPA activity was greater with evening than morning exercise. The inactive group exhibited greater PAI-1 E nhanced fibrinolytic activity is often listed as a benefit of regular participation in physical exercise; however, little is known about the fibrinolytic responses to exercise and potential differences that may exist between physically active and inactive individuals. Although it is well documented that shortterm physical exercise increases fibrinolytic activity, 1 -5 most studies describe global fibrinolytic activity and have not measured the fibrinolytic components tissue plasminogen activator (TPA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1). In addition, few studies that examined fibrinolytic responses to exercise have controlled for the physical activity status of subjects. Studies measuring global fibrinolytic activity 5 and the fibrinoh/tic components 6 report that the activity status of subjects significantly influences the magnitude of change in fibrinolytic variables in response to maximal exercise. Furthermore, few studies have described the responses to a typical submaximal exercise session.Resting fibrinolytic activity is lowest in the morning and increases throughout the day. "11 Lower morning values have been attributed to low TPA activity and high PAI-1 activity.712 These resting diurnal variations appear to affect the fibrinolytic response to exercise. Data from our laboratory 13 suggest that evening exercise produces greater increases in TPA activity than morning exercise. We are aware of only one other study that has examined the effects of exercise performed at Received March 18, 1994; revision accepted August 31, 1994. From the Department of Physical Education, Northern Illinois University, DeKalb (L.M.S.), and the Department of Exercise Science, University of South Carolina, Columbia (R.R.P.).Correspondence to Linda M Szymanski, PhD, Department of Physical Education, Northern Illinois University, DeKalb, IL 60115.© 1994 American Heart Association, Inc.activity than the active group. PAI-1 activity was higher during the morning than evening but did not change with exercise for either group. We conclude that moderate intensity exercise increases TPA activity in physically active and inactive men, with greater increases seen in active men, particularly during ...

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men.

Szymanski

Pate

1994

Arterioscler Thromb

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“…Physical training is known to be a factor increasing the fibrinolytic activity [21], and lack of physical activity has been implicated as a pathogenetic factor in coronary artery disease [22].…”

Section: Introductionmentioning

confidence: 99%

Changes in Plasminogen Activator Inhibitor 1 and Tissue-Type Plasminogen Activator during Exercise in Patients with Coronary Artery Disease

Rydzewski¹,

Sakata

Kobayashi

et al. 1990

Pathophysiol Haemos Thromb

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As depressed fibrinolysis is implicated in the pathogenesis of coronary artery disease, we have studied the activation of fibrinolysis during maximal, symptom-limited exercise in a group of 68 men. After exercise they were divided, according to their coronary angiography and exercise ²⁰¹T1 emission computed tomography results, into three groups. Group 1: persons with normal exercise ²⁰¹T1 emission computed tomography results and no underlying diseases who served as controls; group 2: patients with coronary artery disease without exercise-induced myocardial ischemia, and group 3: patients with coronary artery disease with transient, exercise-induced myocardial ischemia. Before and at peak exercise we measured the plasminogen activator activity (PAA) in the euglobulin fraction of plasma by an amidolytic method and the concentrations of tissue plasminogen activator (t-PA), activator-inhibitor complex – plasminogen activator inhibitor 1 (PAI-1) complexed with t-PA -and total PAI-1 by enzyme immunoassay. The concentration of free PAI-1 in plasma was calculated by subtraction of the concentration of activator-inhibitor complex from that of total PAI-1. Under basal conditions, group 3 had significantly higher free and total PAI-1 levels than group 1. There were no statistically significant differences between the three groups in PAA, t-PA, and activator-inhibitor complex levels. At peak exercise, group 1 showed the highest release of t-PA accompanied with highest increases in PAA as well as in activator-inhibitor complex, the proportion of released t-PA antigen not bound to PAI-1 being highest in group 1. Free PAI-1 decreased significantly, but there were no differences between individual groups. Our results indicate that increased PAI-1 levels in plasma and decreased release of t-PA from endothelial stores play a role in impairment of fibrinolysis in coronary artery disease. These disturbances are more pronounced in patients who develop myocardial ischemia during exercise.

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“…Experimental data on changes of haemostatic parameters after exposure to dry heat (e.g. sauna) as well as after physical activity, which is also regularly accompanied by an increase in body core temperature, show an activation of the intrinsic system of coagulation as well as an activation of the Wbrinolytic system (Bedrak et al 1963(Bedrak et al , 1964El-Sayed et al 2000;Günther et al 1965;Miettinen 1960;Roecker et al 1990Roecker et al , 1996Speiser et al 1988;StreiV and Bell 1994;Weiss et al 1998). In contrast to the numerous data on changes of the haemostatic system after exposure to physical exercise, there appears to exist only limited data on the changes of coagulation and Wbrinolysis after exposure to warm water baths in humans (Zwierzina et al 1980).…”

Section: Introductionmentioning

confidence: 97%

Changes in the haemostatic system after thermoneutral and hyperthermic water immersion

Boldt

Fraszl

Röcker³

et al. 2007

Eur J Appl Physiol

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Warm water bathing is a popular recreational activity and is frequently used in rehabilitation medicine. Although well tolerated in most cases, there are reports indicating an increased risk of thrombotic events after hot tub bathing. The effects of a 45 min thermoneutral bath followed by a 50 min bath with increasing water temperature (maximum 41 degrees C) until reaching a body core temperature of 39 degrees C on factors of blood coagulation and fibrinolysis were studied in eight healthy male volunteers. Blood was obtained after a 45-min resting period as control and after the thermoneutral and hyperthermic bath as well as after another 45 min recovery period at the end of the study. Hyperthermic immersion (HI) lead to a shortening of activated partial thromboplastin time (aPTT) (P < 0.05). Fibrinogen concentration decreased immediately after HI (P < 0.05) but increased during recovery (P < 0.05). Plasminogen activator inhibitor (PAI) activity decreased during HI (P < 0.05), D-dimer concentration was not found to change. Thrombocyte count increased (P < 0.05) during HI. The increases in tissue-type plasminogen activator concentration as well as leucocyte count during HI were due to haemoconcentration. Prothrombin time, PAI-activity and granulocyte count decreased during thermoneutral immersion (P< 0.05). Warm water bathing leads to haemoconcentration and minimal activation of coagulation. The PAI-1 activity is decreased. A marked risk for thrombotic or bleeding complications during warm water bathing in healthy males could not be ascertained.

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Increased blood fibrinolytic activity after physical exercise: Comparative study in individuals with different sporting activities and in patients after myocardial infarction taking part in a rehabilitation sports program

Cited by 90 publications

References 30 publications

Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men.

Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men.

Changes in Plasminogen Activator Inhibitor 1 and Tissue-Type Plasminogen Activator during Exercise in Patients with Coronary Artery Disease

Changes in the haemostatic system after thermoneutral and hyperthermic water immersion

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