Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men.

Szymanski, Linda M.; Pate, Russell R.

doi:10.1161/01.atv.14.11.1746

Cited by 37 publications

(32 citation statements)

References 41 publications

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“…Similar results in increases in tPA after an acute bout of aerobic exercise has been shown by Syzmanski et al (52). Fourteen physically inactive men (mean age, 34.7 ± 4.0 years; mean VO2 max , 38.6 ± 5.6 ml·kgˉ¹·minˉ¹) were compared to 12 regularly active men (mean age, 34.8 ± 4.0 years; mean VO2 max 51.4 ± 3.9 ml·kgˉ¹·minˉ¹) during two different treadmill exercise sessions at 50% of subject"s VO2 max for 30 minutes.…”

Section: Acute Exercise and Fibrinolysissupporting

confidence: 89%

The effects of whole body vibration and exercise on fibrinolysis in men

Boyle

Nagelkirk

2010

Eur J Appl Physiol

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Section: Acute Exercise and Fibrinolysissupporting

confidence: 89%

The effects of whole body vibration and exercise on fibrinolysis in men

Boyle

Nagelkirk

2010

Eur J Appl Physiol

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“…Although existing research has not explored the effects of acute maximal exercise on fibrinolytic variables in postmenopausal women, our results are similar to existing data on other populations (33,45). Szymanski et al (44,45) found that tPA activity was not different at rest between active and inactive men, but the active men exhibited a significantly greater increase in tPA activity after maximal exercise. Similar results were also noted after submaximal exercise, although the groups were not as highly differentiated as after maximal exercise (44).…”

Section: Fig 2 Basal and Postexercise Tpa (A) And Pai-1 (B) Antigensupporting

confidence: 89%

“…Longitudinal evidence also supports this notion (9,38,42). However, differences between physically fit and unfit individuals are not always present at rest but become exacerbated with a stressor, such as a maximal exercise test (44,45). Thus maximal exercise testing can be used to better differentiate the fibrinolytic response between groups compared with using only resting levels of fibrinolysis (44,45).…”

mentioning

confidence: 94%

“…However, differences between physically fit and unfit individuals are not always present at rest but become exacerbated with a stressor, such as a maximal exercise test (44,45). Thus maximal exercise testing can be used to better differentiate the fibrinolytic response between groups compared with using only resting levels of fibrinolysis (44,45). Interestingly, physical fitness may have a more potent impact on endogenous fibrinolysis, particularly in response to maximal exercise, than other conditions known to adversely affect endogenous fibrinolysis, such as aging or CVD (11,17).…”

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confidence: 99%

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Relationship of physical fitness, hormone replacement therapy, and hemostatic risk factors in postmenopausal women

Szymanski¹,

Kessler²,

Fernhall³

2005

Journal of Applied Physiology

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Relationship of physical fitness, hormone replacement therapy, and hemostatic risk factors in postmenopausal women. J Appl Physiol 98: 1341-1348, 2005. First published December 10, 2004 doi:10.1152/ japplphysiol.00622.2004.-This cross-sectional study evaluated the relationship of physical fitness, hormone replacement therapy (HRT), and hemostatic profiles at rest and after an acute bout of maximal exercise in 48 healthy postmenopausal women. Subjects were categorized by fitness and HRT user status into four groups: unfit nonusers, fit nonusers, unfit users, and fit users. Fibrinolytic variables tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) activity, and antigen and prothrombin fragment 1 ϩ 2, a molecular marker of in vivo thrombin generation, were measured before and after maximal exercise. Fibrinogen was also measured at rest. Higher tPA and lower PAI-1 activities (P Ͻ 0.05) were seen in HRT users and fit groups. tPA and PAI-1 antigens were lower in HRT and fit groups (P Ͻ 0.05) but not after correction for body mass index. Prothrombin fragment 1 ϩ 2 was lower in the fit groups regardless of HRT status (P Ͻ 0.05). Fibrinogen was similar in all groups. Favorable hemostatic profiles were observed in physically fit compared with unfit women, especially in HRT nonusers. Thus fitness is more strongly related to these hemostatic risk factors compared with HRT since HRT did not affect these hemostatic variables in fit postmenopausal women.

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“…Although behavioral or environmental factors such as activity level could also influence PAI-1, our 15-minute mild stress tests likely did not capture the full range of PAI-1 changes that can be induced by behavior. 14,15 This complexity is highlighted by a study that found a blunted PAI-1 rhythm in 2 blind individuals who were not synchronized to the 24-hour light/dark cycle. 16 In animals, lesioning the central circadian pacemaker (suprachiasmatic nucleus) abolished the daily rhythm in PAI-1 17 but also abolished behavioral rhythmicity so it could not be determined if the PAI-1 rhythm is driven directly by the circadian system or indirectly through behavior.…”

Section: Resultsmentioning

confidence: 99%

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

Scheer

Shea

2014

Blood

132

105

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• The human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences.• The circadian system determines to a large extent the PAI-1 rhythm observed during a regular sleep/wake cycle.Serious adverse cardiovascular events peak in the morning, possibly related to increased thrombosis in critical vessels. Plasminogen activator inhibitor-1 (PAI-1), which inhibits fibrinolysis, is a key circulating prothrombotic factor that rises in the morning in humans. We tested whether this morning peak in PAI-1 is caused by the internal circadian system or by behaviors that typically occur in the morning, such as altered posture and physical activity. Twelve healthy adults underwent a 2-week protocol that enabled the distinction of endogenous circadian effects from behavioral and environmental effects. The results demonstrated a robust circadian rhythm in circulating PAI-1 with a peak corresponding to ∼6:30 AM. This rhythm in PAI-1 was 8-times larger than changes in PAI-1 induced by standardized behavioral stressors, including head-up tilt and 15-minute cycle exercise. If this large endogenous morning peak in PAI-1 persists in vulnerable individuals, it could help explain the morning peak in adverse cardiovascular events. (Blood. 2014;123(4):590-593) IntroductionThe ability to clot blood can be life-saving after an injury, but thrombi within vessels can contribute to myocardial infarction, ischemic stroke, and sudden cardiac death. 1-3 Ongoing fibrinolytic activity helps break down thrombi and maintain vessel patency and is largely managed by circulating tissue plasminogen activator, which converts plasminogen to plasmin.1-3 Fibrinolytic activity is significantly reduced in the morning due to an increase in plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of tissue plasminogen activator.1-3 Thus, increased PAI-1 and decreased fibrinolysis in the morning may increase the risk for development of occlusive thrombi and could help explain the morning peak in adverse cardiovascular events. [1][2][3][4] To begin to understand potential underlying mechanisms in humans, we tested the degree to which the morning increase in PAI-1 is caused by a direct endogenous circadian rhythm in PAI-1 [5][6][7][8] vs influences from the daily behavioral/environmental changes across the night and day (eg, rest/activity, fasting/feeding, dark/light, and ambient-temperature cycles). MethodsWe studied 12 healthy volunteers taking no medications (mean [range], 25.8 [20-42] years; body mass index, 23.6 [19.9-29.6] kg/m 2 ; 6 women). Studies were approved by the Partners Human Research Committee, and participants gave written informed consent in accordance with the Declaration of Helsinki.Participants were assessed throughout a 2-week laboratory protocol designed to desynchronize daily behavioral rhythms from internal circadian rhythms, while maintaining environmental factors constant. Participants had 2 baseline 24-hour days in normal room lighting conditions (;90 lux wak...

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Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men.

Cited by 37 publications

References 41 publications

The effects of whole body vibration and exercise on fibrinolysis in men

The effects of whole body vibration and exercise on fibrinolysis in men

Relationship of physical fitness, hormone replacement therapy, and hemostatic risk factors in postmenopausal women

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

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