Incidence of Diabetes Mellitus After Kidney Transplantation in Slovakia: Multicentric, Prospective Analysis

Dedinská, L.; Baltesová, T.; Beňa, Ľ; Cellar, M; Galajda, Péter; Chrastina, Martin; Jurčina, A.; Kováčiková, Lea; Laca, Ľ; Lacková, E; Valachová, S. Lauková; Miklušica, Juraj; Rosenberger, Jaroslav; Sersenova, M; Skálová, Petra; Žilinská, Zuzana; Mokáň, Marián

doi:10.1016/j.transproceed.2016.09.041

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…The authors assume that this is possibly the reason for the high incidence of DMPT. [21] The most prevalent type of transplant in this study was the kidney transplant. This finding corroborates Dedinská et al, [21] results that indicate an increase in the incidence of DM post-kidney transplantation (15%-30%), associated with a high prevalence of overweight, obesity, and end-stage renal disease.…”

Section: Discussionmentioning

confidence: 93%

Self-care of liver, kidney and bone marrow transplant patients with diabetes

Chagas

Negreiros

Moreira

et al. 2021

JNEP

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Self-care is a set of actions that individuals take to maintain life, good health, and well-being. Regardless of the type of diabetes, individuals must perform self-care and comply with the treatment to prevent complications, achieve better disease management, and maintain their quality of life. This study aimed to examine self-care behaviors of liver, kidney, and bone marrow transplant patients with diabetes. The study has used a descriptive correlational design and was carried out in an endocrinology and diabetes center in Brazil. A total of 101 patients participated in the study. The Diabetes Self-care Activities Questionnaire was used, and the quantitative analysis was carried out using SPSS. The results show that the highest self-care levels occurred in the medication domain, while the lowest were found in the specific diet domain. Some important correlations were found: men were more likely to assess blood glucose, use combined oral/insulin therapy, take insulin, and take medications as prescribed than women; patients on combined oral/insulin therapy followed dietary recommendations more frequently than the others; and patients with altered serum urea and history of stroke had high levels of self-care. The results made it possible to know the compliance in performing self-care activities in transplanted patients with diabetes, supporting the development of interventions to motivate and improve self-care.

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Section: Discussionmentioning

confidence: 93%

Self-care of liver, kidney and bone marrow transplant patients with diabetes

Chagas

Negreiros

Moreira

et al. 2021

JNEP

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“…As previously described, the prevalence of PTDM is variable, with values ranging from 10% to 74%, according to region, population characteristics, and diagnostic criteria ( 25 ). A multicenter observational study in South Korea found an incidence of 11.8% within the first year post-transplant ( 26 ), while another trial from Slovak Republic showed an incidence of 38,3% in the same period ( 27 ). Considering the time post-transplant for PTDM diagnosis, most reported cases occurred during the first year post-transplant, which is probably related to high doses of immunosuppression in this period ( 8 , 28 ).…”

Section: Discussionmentioning

confidence: 99%

Post-transplant diabetes mellitus: risk factors and outcomes in a 5-year follow-up

Rossi,

Mazzali,

de Sousa

2024

Front. Clin. Diabetes Healthc.

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IntroductionKidney transplantation is associated with an increased risk of posttransplant diabetes mellitus (PTDM), impacting recipient and graft survivals. The incidence of PTDM ranges from 15% to 30%, with most cases occurring in the first year post-transplant. Some clinical and laboratory characteristics pre- and post-transplant may be associated with a higher PTDM incidence in a more extended follow-up period. This study aimed to analyze the prevalence of PTDM among renal transplant recipients without previous DM diagnosis during a five-year post-transplant follow-up, as well as clinical and laboratory characteristics associated with a higher incidence of PTDM during this period.Material and methodsSingle-center retrospective cohort including kidney transplant recipients older than 18 years with a functioning graft over six months of follow-up between January and December 2018. Exclusion criteria were recipients younger than 18 years at kidney transplantation, previous diabetes mellitus diagnosis, and death with a functioning graft or graft failure within six months post-transplant.ResultsFrom 117 kidney transplants performed during the period, 71 (60.7%) fulfilled the inclusion criteria, 18 (25.3%) had PTDM diagnosis, and most (n=16, 88.9%) during the 1st year post-transplant. The need for insulin therapy during the hospital stay was significantly higher in the PTDM group (n=11, 61.1% vs. n=14, 26.4%, PTDM vs. non-PTDM). Other PTDM risk factors, such as older age, high body mass index, HLA mismatches, and cytomegalovirus or hepatitis C virus infections, were not associated with PTDM occurrence in this series. During 5-year post-transplant follow-up, the graft function remained stable in both groups.ConclusionThe accumulated incidence of PTDM in this series was similar to the reported in other studies. The perioperative hyperglycemia with the need for treatment with insulin before hospital discharge was associated with PTDM.

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“…It has been postulated, the hypothalamic-pituitary-gonadal axis is permanently altered following ESKD, although the normalization of hormonal status can be altered by immunosuppression (corticosteroids) and other medications (β-blockers) (26). The incidence of posttransplant diabetes mellitus (PTDM) is being reported more than 38.3 % in Slovakia (27). PTDM can cause menstrual disturbances through alterations of hypothalamus-pituitary-gonadal axis (28).…”

Section: Discussionmentioning

confidence: 99%

Age and sex disparity in infectious complications after kidney transplantation

Vnučák¹,

Graňák²,

Beliancinova³

et al. 2022

BLL

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OBJECTIVES: The aim of our analysis was to fi nd whether there are sex and age differences in the incidence of single and repeat infection after kidney transplantation (KT). BACKGROUND: Potent immunosuppression lowers the incidence of acute graft rejection but increases the risk of post-transplant infections. Older adults and females are at high risk of infections leading to poor outcome after KT. MATERIALS: Our analysis consisted of 66 males and 34 females after KT, average age 47.5 ± 12.6 years. RESULTS: Female gender was a RF for the incidence of infection in general (p = 0.0054), recurrent (p =0.0239), bacterial (p = 0.0125) and mycotic infection (p = 0.0103), recurrent bacterial infection (p = 0.0258) 1st month after KT, RF for the incidence of infection in general (p = 0.0218), bacterial (p = 0.0186), mycotic (p =0.0318), recurrent (p = 0.0216), recurrent bacterial infection (p = 0.0368) from 1st to 6th month after KT and RF for the incidence of bacterial (p = 0.0144), single (p = 0.0355), recurrent (p = 0.0007) and single bacterial infection (p=0.0309) 6 months after KT. Age > 60 years was not found as a RF for the incidence of single, repeat infection regarding its aetiology. CONCLUSION: We found signifi cant sex differences in the incidence of single and repeat infections in different time intervals after KT (Tab. 4, Fig. 3, Ref. 31).

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Incidence of Diabetes Mellitus After Kidney Transplantation in Slovakia: Multicentric, Prospective Analysis

Cited by 8 publications

References 18 publications

Self-care of liver, kidney and bone marrow transplant patients with diabetes

Self-care of liver, kidney and bone marrow transplant patients with diabetes

Post-transplant diabetes mellitus: risk factors and outcomes in a 5-year follow-up

Age and sex disparity in infectious complications after kidney transplantation

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