Age and sex disparity in infectious complications after kidney transplantation

Abstract

OBJECTIVES: The aim of our analysis was to fi nd whether there are sex and age differences in the incidence of single and repeat infection after kidney transplantation (KT). BACKGROUND: Potent immunosuppression lowers the incidence of acute graft rejection but increases the risk of post-transplant infections. Older adults and females are at high risk of infections leading to poor outcome after KT. MATERIALS: Our analysis consisted of 66 males and 34 females after KT, average age 47.5 ± 12.6 years. RESULTS: Female gender was a RF for the incidence of infection in general (p = 0.0054), recurrent (p =0.0239), bacterial (p = 0.0125) and mycotic infection (p = 0.0103), recurrent bacterial infection (p = 0.0258) 1st month after KT, RF for the incidence of infection in general (p = 0.0218), bacterial (p = 0.0186), mycotic (p =0.0318), recurrent (p = 0.0216), recurrent bacterial infection (p = 0.0368) from 1st to 6th month after KT and RF for the incidence of bacterial (p = 0.0144), single (p = 0.0355), recurrent (p = 0.0007) and single bacterial infection (p=0.0309) 6 months after KT. Age > 60 years was not found as a RF for the incidence of single, repeat infection regarding its aetiology. CONCLUSION: We found signifi cant sex differences in the incidence of single and repeat infections in different time intervals after KT (Tab. 4, Fig. 3, Ref. 31).

Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review

“…Bacterial infections are most frequent after KT, followed by viral infections, with fungal and parasitic infections being much rarer 34,36,42,43 . UTI after KT are the most common infectious complication, albeit with decreasing prevalence since the 1990s 34,42,44,45 . In a meta‐analysis of 13 studies ( n = 3 364), the pooled prevalence of UTIs in KT recipients was 38.0% (95% CI, 29%–47%; p < .01) 35 .…”

“…Overall, infections are the predominant cause for hospital readmission within the first year following KT (49%, n = 202/296) 41 . Bacterial infections are most frequent after KT, followed by viral infections, with fungal and parasitic infections being much rarer 34,36,42,43 . UTI after KT are the most common infectious complication, albeit with decreasing prevalence since the 1990s 34,42,44,45 .…”