Incidence and risk factors of neonatal thrombocytopenia: a pr

Abstract

Background Thrombocytopenia is the most common hematological abnormality in the neonatal period. Hemorrhagic manifestations are found in 10% cases of thrombocytopenia. Neonatal thrombocytopenia commonly assumed due to sepsis, despite many risk factors that may caused thrombocytopenia. Objective To obtain incidence and risk factors of neonatal thrombocytopenia. Methods A cross sectional study was conducted in April 2009. Complete blood counts investigation was performed before age of 24 hours, medical conditions and risk factors of mothers and subjects were noted, as well as hemorrhagic manifestations. Subjects with thrombocytopenia were followed for 2 weeks. The risk factors consisted of hypertension in pregnancy, pre-eclampsia, eclampsia, intrauterine growth retardation, gestational diabetes mellitus, perinatal infection, asphyxia, sepsis, and necrotizing enterocolitis. Results Neonatal thrombocytopenia was found 17 (12.1%) of 140 subjects, consisted of 88.2% early onset and 11.8% late onset. Significant risk factor of mother was pre-eclampsia (PR 3.97, 95%CI 1.70 to 9.25), while significant risk factors of neonates were asphyxia (PR 5.66, 95%CI 2.49 to 12.86), sepsis (PR 5.33,) and necrotizing enterocolitis (p=0.014; PR 9.2 95% CI 5.17 to14.84). We found 29.4% hemorrhagic cases of neonatal thrombocytopenia (i.e.,. skin, gastrointestinal, intracranial hemorrhage). Conclusions The incidence of neonatal thrombocytopenia was 12.2%. Significant risk factor of mother that caused thrombocytopenia was pre-eclampsia, while risk factors of neonates were asphyxia, sepsis and necrotizing enterocolitis.

Incidence and Risk Factors of Thrombocytopenia in Neonates Admitted with Surgical Disorders to Neonatal Intensive Care Unit of Tikur Anbessa Specialized Hospital: A One-Year Observational Prospective Cohort Study from a Low-Income Country

“… 17 , 20 , 21 , 23 Neonates with low birth weight constituted for one fifth of our study population which compares well to a study from Indonesia (20.7%) but higher than a report from Nigeria (13.6%) and significantly lower than India (62.5%). 18 , 20 , 22 …”

“…This figure is significantly lower compared to other reports from India (13.5%), Iran (17.7%), Indonesia (24.3%) and Iran (57.1%). [18][19][20][21] Male neonates constituted for more than half (56.2%) of our study population which is comparable to a study from Iran (51.3%). 19 However, this figure was found to be higher than reports from Indonesia (48.6%) and Nigeria (42.4%) but lower than a study from Saudi Arabia (70.4%).…”

“…In our study the incidence of thrombocytopenia was found to be 55.8% which is comparable to a report from Nigeria 53% but significantly higher from studies from India (16.7%), Iran (17.9%), Indonesia (12.1%), and the Netherlands (27%). 11 , 19 , 20 , 24 , 25 This difference may be explained by the variability of the types and magnitude of the risk factors involved in the development of thrombocytopenia in each set up. In the great majority (90.9%) of the neonates with thrombocytopenia, the onset was >72 hrs from birth.…”

Thrombocytopenia: Diagnostic Tool of Neonatal Infection?

“…A similar study carried out in Indonesia showed that thrombocytopenia in the children hospitalized at the NICU was 12% [9]. On the other hand, a research published in 2009 suggests that thrombocytopenia was confirmed in laboratory test results in 22% to 35% newborn hospitalized at the NICU [10].…”

The relationship between thrombocytopenia and intraventricular hemorrhage in neonates with gestational age <35 weeks

“…The incidence of thrombocytopenia in neonates was 12.1% in Cipto Mangunkusumo Hospital (CMH). 11 Another study in CMH found that the incidence of IVH in neonates with gestational age <35 weeks was 43.47%, of which 7.6% had severe IVH, but it had no analysis of thrombocytopenia as a potential factor contributing to the occurrence of IVH. 12 The high incidence of IVH highlights the urgency of this study to assess for a relationship between thrombocytopenia and IVH in neonates with gestational age <35 weeks.…”