The relationship between thrombocytopenia and intraventricular hemorrhage in neonates with gestational age &lt;35 weeks

Yulandari, Idha; Rundjan, Lily; Kadim, Muzal; Amalia, Pustika; Wulandari, Haryanti Fauziah; Handryastuti, Setyo

doi:10.14238/pi56.4.2016.242-50

Cited by 4 publications

(2 citation statements)

References 21 publications

(43 reference statements)

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“…Prematurity and low birthweight were associated with IVH. 61 Although the main treatment for IVH is surgery and medications, optimalization of nutritional intake is important to avoid complications and improving the outcomes, especially after invasive methods. 62…”

Section: Intraventricular Hemorrhagementioning

confidence: 99%

Nutritional Management and Recommendation for Preterm Infants: A Narrative Review

Rohsiswatmo

2021

AMNT

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Background: Preterm birth is defined as birth before 37 completed weeks of pregnancy. It is the most important predictor of adverse health and development infant outcomes that extend into the early childhood and beyond. It is also the leading cause of childhood mortality under 5 years of age worldwide and responsible for approximately one million neonatal deaths. It is also a significant contributor to childhood morbidities, with many survivors are facing an increased risk of lifelong disability and poor quality of life. Purpose: In this article, we aimed to describe features of preterm infants, what makes them different from term infants, and what to consider in nutritional management of preterm infants through a traditional narrative literature review. Discussion: Preterm infants are predisposed to more health complications than term infants with higher morbidity and mortality. This morbidity and mortality can be reduced through timely interventions for the mother and the preterm infant. Maternal interventions, such as health education and administration of micronutrient supplementation, are given before or during pregnancy and at delivery, whereas appropriate care for the preterm infants should be initiated immediately after birth, which include early breastfeeding and optimalization of weight gain. Conclusion: Essential care of the preterm infants and early aggressive nutrition should be provided to support rapid growth that is associated with improved neurodevelopmental outcomes. The goal is not only about survival but making sure that these preterm infants grow and develop without any residual morbidity.

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Section: Intraventricular Hemorrhagementioning

confidence: 99%

Nutritional Management and Recommendation for Preterm Infants: A Narrative Review

Rohsiswatmo

2021

AMNT

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“…Hemorrhagic morbidities such as intraventricular hemorrhage, pulmonary and gastrointestinal bleedings increase the risk of mortality especially in preterm newborns [14, 15]. However, many newborns who develop hemorrhagic disorders are not thrombocytopenic [16]. This implies that endogenously produced circulating platelets may not adequately provide the needed hemostatic support [17].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Neutrophil Interactions Are Lower in Cord Blood of Premature Newborns

et al. 2018

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Objective: To quantify platelet-neutrophil interaction by flow cytometry, in newborn cord blood, as a function of gestational age. Rationale: Little is known about platelet function markers in the newborn, and developmental variations in these markers are not well described. Methods: Cord blood samples were obtained from 64 newborns between 23 and 40 weeks’ gestation. The neonates were grouped into three categories: preterm (< 34 weeks’ gestation, n = 21), late preterm (34 to < 37 weeks’ gestation, n = 22), and term (≥37 weeks’ gestation, n = 21). We monitored the expression of P-selectin and the formation of platelet-neutrophil aggregates (PNAs) by flow cytometry while using adenosine 5′-diphosphate (ADP) or thrombin receptor-activating peptide (TRAP) as agonists. Results: PNAs were significantly lower in preterm compared to term neonates after TRAP or ADP stimulations (11.5 ± 5.2% vs. 19.9 ± 9.1%, p < 0.001, or 24.0 ± 10.1% vs. 39.1 ± 18.2%, p = 0.008, respectively). The expression of P-selectin also tended to be lower in preterm neonates, with significant positive correlations between P-selectin expression and PNA formation. Conclusions: The potential formation of PNAs correlates with gestational age. This suggests that the development of functional competencies of platelets and neutrophils continues throughout gestation, progressively enabling interactions between them.

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Historical Perspectives: Low Birthweight and Preterm Infants in Indonesia

Haksari

2019

NeoReviews

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The incidence of infants with low birthweight (LBW), prematurity, and small for gestational age (SGA) in Indonesia remains high, and the morbidity and mortality in these infants are significant. To study these groups of infants in Indonesia, the author searched PubMed/Medline, the Cochrane Library, Google, Indonesian reports, local publications, and doctoral and master theses in English and Indonesian from 1987 to February 2019. In this review, the development of local reference growth charts of infants born in Indonesia is described, as well as the importance of these curves in defining the prevalence of SGA infants. Some of the risk factors associated with LBW, preterm, and SGA Indonesian infants are described. The author also discusses the effectiveness of specific interventions, such as kangaroo mother care, early initiation of enteral feedings, increased breastfeeding rates, and identifying the optimal timing of hospital discharge. Some of the morbidities associated with LBW infants born in Indonesia are described. Advances in hospital care and postdischarge follow-up of LBW, preterm, and SGA infants born in Indonesia are critical to decrease the morbidity and mortality rates associated with these populations.

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The relationship between thrombocytopenia and intraventricular hemorrhage in neonates with gestational age <35 weeks

Abstract: Background The prevalence of thrombocytopenia in neonates

Cited by 4 publications

References 21 publications

Nutritional Management and Recommendation for Preterm Infants: A Narrative Review

Nutritional Management and Recommendation for Preterm Infants: A Narrative Review

Platelet-Neutrophil Interactions Are Lower in Cord Blood of Premature Newborns

Historical Perspectives: Low Birthweight and Preterm Infants in Indonesia

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