Inactivation of Native K Channels

Kodirov, Sodikdjon A.; Brachmann, Johannes; Safonova, T. A.; Zhuravlev, V. L.

doi:10.1007/s00232-021-00195-w

Cited by 4 publications

(2 citation statements)

References 53 publications

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“…Regrettably, Figure 2b is based on cut, copy and paste approach along the horizontal stretching − “decreased rate” to mimic hypothetical insufficient wash‐out effects (Figures 2−4). The latter is unnecessary, especially for invertebrates, as responses and signals in simpler animal models are reproducible and robust (Kodirov, 2011; Kodirov et al, 2021; S.‐Rozsa, 1979; Zhuravlev et al, 2001).…”

Section: Neither Ca2+ Clock Nor Hcn Is a Dominant Pacemakermentioning

confidence: 99%

Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

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Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.

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Section: Neither Ca2+ Clock Nor Hcn Is a Dominant Pacemakermentioning

confidence: 99%

Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

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“…Earlier studies used the reversal potential ( E rev ) of K currents as a HP to activate the Kv and Nav channels (Frankenhaeuser, 1962; Kodirov, 2020). Besides, all Kv channels exhibit more specific HP dependencies, and are separated using different and adequate values in the same cells sequentially (Kodirov et al, 2022). Note that in LNV injection of only −20 pA currents leads to hyperpolarization of RMP by ~30 mV (Sheeba et al, 2008).…”

Section: K Currents In Drosophilamentioning

confidence: 99%

Functioning of K channels during sleep

Kodirov

2022

Arch Insect Biochem Physiol

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The functioning of voltage-dependent K channels (Kv) may correlate with the physiological state of brain in organisms, including the sleep in Drosophila. Apparently, all major types of K currents are expressed in CNS of this model organism. These are the Shab-Kv2, Shaker-Kv1, Shal-Kv4, and Shaw-Kv3 α subunits and can be deciphered by patch-clamp technique. Although it is plausible that some of these channels may play a prevailing role in sleep or wakefulness, several of recent data are not conclusive. It needs to be defined that indeed the frequency of action potentials in large ventral lateral pacemaker neurons is either higher or lower during the morning or night because of an increased Kv3 and Kv4 currents, respectively. The outcomes of dynamic-clamp approach in combination with electrophysiology in insects are unreliable in contrast to those in mammalian neurons. Since the addition of virtual Kv conductance during any Zeitgeber time should not significantly alter the resting membrane potential. This review explains the Drosophila sleep behavior based on neural activity with respect to K current-driven action potential rate.

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Whole-cell patch-clamp recording and parameters

Kodirov

2023

Biophys Rev

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Inactivation of Native K Channels

Cited by 4 publications

References 53 publications

Probability that there is a mammalian counterpart of cardiac clock in insects

Probability that there is a mammalian counterpart of cardiac clock in insects

Functioning of K channels during sleep

Whole-cell patch-clamp recording and parameters

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