Probability that there is a mammalian counterpart of cardiac clock in insects

Abstract

Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.

Functioning of K channels during sleep

“…The unique properties of Drosophila K currents, especially those of ether a go go related gene (ERG) K channel stimulated numerous studies in other organs and species along the pathologies (Ivanov et al, 2003; Roden, 2019; Sanchez et al, 1998; Tanouye & Ferrus, 1985; Warmke et al, 1991). Thus, the Drosophila is an important experimental model for many aspects of genetics and physiology of organs (Burdina et al, 2021; Kodirov, 2022).…”