Abstract:The functioning of voltage-dependent K channels (Kv) may correlate with the physiological state of brain in organisms, including the sleep in Drosophila. Apparently, all major types of K currents are expressed in CNS of this model organism. These are the Shab-Kv2, Shaker-Kv1, Shal-Kv4, and Shaw-Kv3 α subunits and can be deciphered by patch-clamp technique. Although it is plausible that some of these channels may play a prevailing role in sleep or wakefulness, several of recent data are not conclusive. It needs… Show more
“…The HERG gene was discovered in Drosophila , a truly insightful experimental model with genetic and physiological implications (Kodirov, 2022). Another distinguishing feature of the HERG channel is its deactivation—tail, which results in more facilitated currents than the main component (Figure 2b).…”
“…The HERG gene was discovered in Drosophila , a truly insightful experimental model with genetic and physiological implications (Kodirov, 2022). Another distinguishing feature of the HERG channel is its deactivation—tail, which results in more facilitated currents than the main component (Figure 2b).…”
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