In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor

Zhao, Dingtao; Wang, Tingting; Kuhlmann, Julia; Dong, Zhongyun; Chen, Shuna; Joshi, Madhura; Salunke, Pravahan; Shanov, Vesselin; Hong, Dae-Ki; Kumta, Prashant N.; Heineman, William R.

doi:10.1016/j.actbio.2016.03.039

Cited by 48 publications

(53 citation statements)

References 55 publications

(87 reference statements)

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“…The sensor-based monitoring system may have some overlaps with that of electrochemicalbased. A set-up developed by Zhao et al [71] can be put in this category. In this non-invasive set-up Another electrochemical-based system was developed to monitor the real-time corrosion of Mg, namely the corrosion characterization system [67].…”

Section: Sensor-based Monitoring Systemmentioning

confidence: 99%

“…The sensor-based monitoring system may have some overlaps with that of electrochemical-based. A set-up developed by Zhao et al [71] can be put in this category. In this non-invasive set-up (Figure 7a), the real-time concentration of hydrogen gas is measured by a micro-sensor, and they used it to study the corrosion behavior of an Mg alloy in-vivo (Figure 7b).…”

Section: Sensor-based Monitoring Systemmentioning

confidence: 99%

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In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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Absorbable metals have been introduced as materials to fabricate temporary medical implants. Iron, magnesium and zinc have been considered as major base elements of such metals. The metallurgical characterization and in-vitro corrosion assessment of these metals have been covered by the new ASTM standards F3160 and F3268. However, the in-vivo corrosion characterization and assessment of absorbable metal implants are not yet well established. The corrosion of metals in the in-vivo environment leads to metal ion release and corrosion product formation that may cause excessive toxicity. The aim of this work is to introduce the techniques to assess absorbable metal implants and their in-vivo corrosion behavior. This contains the existing approaches, e.g., implant retrieval and histological analysis, ultrasonography and radiography, and the new techniques for real-time in-vivo corrosion monitoring.

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Section: Sensor-based Monitoring Systemmentioning

confidence: 99%

Section: Sensor-based Monitoring Systemmentioning

confidence: 99%

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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“…These parameters could be used to model the degradation process and the formation of the interface in vivo, providing indirect information about the degradation layer. The release of H 2 can be monitored optically or electrochemically from outside of the body 28,29 if the implant is placed subcutaneously. These measurements allow noninvasive quantification of H 2 but not permanent monitoring of its evolution.…”

Section: Introductionmentioning

confidence: 99%

The Interface Between Degradable Mg and Tissue

Willumeit‐Römer

2019

JOM

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Magnesium (Mg) and its alloys degrade under physiological conditions, which makes them interesting implant materials, especially for osteosynthesis and cardiovascular applications. However, how strong is the connection between the implant, the degradation layer, and the surrounding tissue, namely bone? Considering that microscopically the interface can be separated into the border between the metal and the degradation layer, the degradation layer itself, and the border between the degradation layer and the biological environment, it is not obvious that this zone with total thickness of several tens of microns is sufficient to keep an implant in place. However, biomechanical approaches such as push-out tests have shown that a degraded Mg pin is surprisingly well connected with the bone irrespective of the fragile appearance of the degradation layer. This paper provides an overview of what is known about the interface between degrading Mg implants, cells, and bone tissue.

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“…Our group has used an electrochemical (amperometric) H2 sensor to monitor the corrosion process of implanted rare earth-containing Mg alloys, other Mg alloys and high purity Mg single crystal disks in mice [22,30,31]. One study showed that there is little difference between the H2 concentration inside a gas cavity associated with a subcutaneous implant and a transdermal measurement made on the skin above the implant [30,31]. This observation confirmed the extraordinarily fast transport of H2 through biological tissues such as skin, which also means that H2 levels in vivo can potentially be tracked noninvasively by a H2 sensor measuring transdermally by simply pressing it against the skin.…”

Section: Introductionmentioning

confidence: 99%

Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo

et al. 2016

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Biodegradable Mg implants offer advantages over permanent implants such as stainless steel that are used for broken bone repair. Mg alloys gradually dissolve, avoiding the need for removal by a later surgery if complications arise. Here we report a visual H sensor that can be used in the research laboratory to monitor the corrosion process in vivo during animal testing of different Mg alloys. The sensor consists of a plastic sheet with a thin coating that changes color in the presence of H gas. The sensor is easily used by taping it on the skin over the Mg implant. The color change gives a map of the H level permeating from the degrading Mg through the skin above it. This low cost, simple method of monitoring the dissolution of biodegradable implants would greatly facilitate the development of the biodegradable materials, especially in animal studies where in vivo biodegradation is tested.

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In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor

Cited by 48 publications

References 55 publications

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

The Interface Between Degradable Mg and Tissue

Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo

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