Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo

Zhao, Dingtao; Wang, Tingting; Hoagland, William; Benson, David; Dong, Zhongyun; Chen, Shuna; Chou, Da-Tren; Hong, Dae-Ki; Wu, Jingyao; Kumta, Prashant N.; Heineman, William R.

doi:10.1016/j.actbio.2016.08.049

Cited by 28 publications

(38 citation statements)

References 40 publications

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“…In this non-invasive set-up (Figure 7a), the real-time concentration of hydrogen gas is measured by a micro-sensor, and they used it to study the corrosion behavior of an Mg alloy in-vivo (Figure 7b). In spite of the low level of the permeated hydrogen through the skin (30-400 µM), the sensor was able to detect it in a short response time of 30 s. This was depicted in the 3D visualization of the hydrogen permeation (Figure 7c) [72]. More thorough understanding of the corrosion behavior of Mg was achieved using Inductively-Coupled Plasma Mass Spectrometry (ICP-MS) and XPS as complementary characterization techniques.…”

Section: Sensor-based Monitoring Systemmentioning

confidence: 99%

“…Sensor-based corrosion monitoring system: (a) hydrogen micro-sensor assembled on a micromanipulator for measuring hydrogen transdermally from a Mg alloy implanted subcutaneously in a mouse where the sensor tip is in a direct contact with the mouse skin; (b) photograph of an anaesthetized nude mouse with marked measurement points, and color development of thin film visual hydrogen sensor at two different observation times; (c) 3D reconstruction of the brightness change in the hydrogen sensor area at 213 min and associated volume change of the Mg implant; (d) design of a fully biodegradable sensor (wireless telemetry with inductive link); (e) resistor-inductor-capacitor (RLC) resonators made of absorbable materials. Adapted with permission from Elsevier and Springer Nature[72,74,75].…”

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confidence: 99%

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In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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Absorbable metals have been introduced as materials to fabricate temporary medical implants. Iron, magnesium and zinc have been considered as major base elements of such metals. The metallurgical characterization and in-vitro corrosion assessment of these metals have been covered by the new ASTM standards F3160 and F3268. However, the in-vivo corrosion characterization and assessment of absorbable metal implants are not yet well established. The corrosion of metals in the in-vivo environment leads to metal ion release and corrosion product formation that may cause excessive toxicity. The aim of this work is to introduce the techniques to assess absorbable metal implants and their in-vivo corrosion behavior. This contains the existing approaches, e.g., implant retrieval and histological analysis, ultrasonography and radiography, and the new techniques for real-time in-vivo corrosion monitoring.

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Section: Sensor-based Monitoring Systemmentioning

confidence: 99%

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confidence: 99%

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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“…These parameters could be used to model the degradation process and the formation of the interface in vivo, providing indirect information about the degradation layer. The release of H 2 can be monitored optically or electrochemically from outside of the body 28,29 if the implant is placed subcutaneously. These measurements allow noninvasive quantification of H 2 but not permanent monitoring of its evolution.…”

Section: Introductionmentioning

confidence: 99%

The Interface Between Degradable Mg and Tissue

Willumeit‐Römer

2019

JOM

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Magnesium (Mg) and its alloys degrade under physiological conditions, which makes them interesting implant materials, especially for osteosynthesis and cardiovascular applications. However, how strong is the connection between the implant, the degradation layer, and the surrounding tissue, namely bone? Considering that microscopically the interface can be separated into the border between the metal and the degradation layer, the degradation layer itself, and the border between the degradation layer and the biological environment, it is not obvious that this zone with total thickness of several tens of microns is sufficient to keep an implant in place. However, biomechanical approaches such as push-out tests have shown that a degraded Mg pin is surprisingly well connected with the bone irrespective of the fragile appearance of the degradation layer. This paper provides an overview of what is known about the interface between degrading Mg implants, cells, and bone tissue.

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“…6 Corrosion monitoring systems: a experimental set-up of in situ and real-time flow-induced electrochemical corrosion study, b experimental set-up of the microdialysis probe-FED biosensor coupling with potentiostat (inset: dialyzate is dropped at the reaction zone of the FED that was immobilized with the GK and GPOx enzymes to detect Mg 2+ ions via enzymes cascade reaction), c hydrogen microsensor assembled on a micromanipulator for measuring hydrogen transdermally from a magnesium alloy implanted subcutaneously in a mouse where the sensor tip is in a direct contact with the mouse skin, d photograph of an anaesthetized nude mouse with marked measurement points, and color development of thin-film visual hydrogen sensor at two different observation times, e 3D reconstruction of the brightness change in the hydrogen sensor area at 213 min and associated volume change of the magnesium implant. Adapted with permission from Elsevier and Springer Nature (Wang et al 2016b ; Zhao et al 2016b , c ; Natasha et al 2018 ) …”

Section: Basic Researchmentioning

confidence: 99%

“… Adapted with permission from Elsevier and Springer Nature (Wang et al 2016b ; Zhao et al 2016b , c ; Natasha et al 2018 ) …”

Section: Basic Researchmentioning

confidence: 99%

Updates on the research and development of absorbable metals for biomedical applications

2018

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Absorbable metals, metals that corrode in physiological environment, constitute a new class of biomaterials intended for temporary medical implant applications. The introduction of these metals has shifted the established paradigm of metal implants from preventing corrosion to its direct application. Interest toward absorbable metals has been growing in the past decade. This is proved by the rapid increase in scientific publication, progressive development of standards, and launching the first commercial products. Iron, magnesium, zinc, and their alloys are the current three absorbable metals families. Magnesium-based metals are the most progressing family with a large data set obtained from both basic and translational research. Iron-based metals are still facing a major challenge of low in vivo corrosion rate despite the significant efforts that have been put to overcome its weakness. Zinc-based metals are the new alternative absorbable metals with moderate corrosion rates that fall between those of iron and magnesium. This manuscript provides a brief review on the latest progress in the research and development of absorbable metals, the most important findings, the remaining challenges, and the perspective on the future direction.Graphical abstract

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Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo

Cited by 28 publications

References 40 publications

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

The Interface Between Degradable Mg and Tissue

Updates on the research and development of absorbable metals for biomedical applications

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