In vivo evaluation of the wound healing properties of bio-nanofiber chitosan/ polyvinyl alcohol incorporating honey and Nepeta dschuparensis

Naeimi, Atena; Payandeh, Maryam; Ghara, Abdollah Ramzani; Ghadi, Fereshteh Ezzati

doi:10.1016/j.carbpol.2020.116315

Cited by 82 publications

(35 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed findings implied that the incorporation of berberine in the electrospun mats did not affect their physico-chemical nature and improved their biological activity in the wound healing [92]. An equal effort has been put forward in the encapsulation of honey and Nepeta dschuparensis plant in polyvinyl alcohol and chitosan electrospun nanofibers for enhanced wound healing [93]. The in vivo studies performed in the rat models have shown a faster wound healing within three weeks for the nanofibers incorporated with honey and plant which implied their potential in effective and faster healing of acute and chronic wounds [93].…”

Section: Composite Nanofibers Based Wound Dressingsmentioning

confidence: 96%

“…An equal effort has been put forward in the encapsulation of honey and Nepeta dschuparensis plant in polyvinyl alcohol and chitosan electrospun nanofibers for enhanced wound healing [93]. The in vivo studies performed in the rat models have shown a faster wound healing within three weeks for the nanofibers incorporated with honey and plant which implied their potential in effective and faster healing of acute and chronic wounds [93]. Bazmandeh and co-workers adopted dual spinneret approach for the fabrication of electrospun nanofibers mimicking fibrous/gel structure of ECM using chitosan-gelatin/ chitosan-hyaluronic acid [94].…”

Section: Composite Nanofibers Based Wound Dressingsmentioning

confidence: 99%

See 1 more Smart Citation

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

View full text Add to dashboard Cite

E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

show abstract

Section: Composite Nanofibers Based Wound Dressingsmentioning

confidence: 96%

Section: Composite Nanofibers Based Wound Dressingsmentioning

confidence: 99%

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

View full text Add to dashboard Cite

show abstract

“…Naeimi and co-workers formulated chitosan–PVA nanofibers loaded with a plant extract called Nepeta dschuparensis and honey for wound healing application. The in vivo wound healing experiments using second-degree burn wound on animal model demonstrated that the wounds treated with nanofibers loaded with Nepeta dschuparensis and honey healed faster with a wound closure percentage of 59.85% ± 0.14 at day 21 when compared with the control group (40.45% ± 0.008), plain nanofiber (37.42% ± 0.008), and silver sulfadiazine (silver topical treatment for burn wounds) (44.28 ± 0.009) [ 72 ].…”

Section: Fabrication Of Biopolymer-based Hybrid Nanofibersmentioning

confidence: 99%

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Alven

Aderibigbe

2021

Polymers

View full text Add to dashboard Cite

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

show abstract

“…combining synthetic polymer (PVA) with CS for the formation of CS/PVA eNFs incorporating honey as bioactive agent, TGA analysis showed a 2 phase degradation, the first weight-loss corresponding with the PVA degradation (250 °C) and the second one (350 °C) with the chitosan ones [ 100 ].…”

Section: Figurementioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

View full text Add to dashboard Cite

Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

show abstract

In vivo evaluation of the wound healing properties of bio-nanofiber chitosan/ polyvinyl alcohol incorporating honey and Nepeta dschuparensis

Cited by 82 publications

References 36 publications

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Contact Info

Product

Resources

About